(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-formylphenyl methacrylate

Base Information

Chemical Name:(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-formylphenyl methacrylate
CAS No.:1390644-39-9
Molecular Formula:C₂₆H₃₃NO₃
Molecular Weight:407.553
Hs Code.:

Synonyms:(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-formylphenyl methacrylate

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Chemical Property of (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-formylphenyl methacrylate

Chemical Property:

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Technology Process of (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-formylphenyl methacrylate

There total 16 articles about (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-formylphenyl methacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 214601-12-4
(R)-N,N-diisopropyl-3-phenyl-3-(5-formyl-2-hydroxyphenyl)propyl-1-amine

: 920-46-7,26937-45-1
Methacryloyl chloride

: 1390644-39-9
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-formylphenyl methacrylate

Guidance literature:: In chloroform; at -45 - -35 ℃; for 0.75h;

Reference yield:

: (+/-)-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropane-1-ol

: 1390644-39-9
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-formylphenyl methacrylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 5 °C

2.1: acetonitrile / 32 h / 95 - 100 °C / autoclave; Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran / 0.75 h / -65 - -55 °C

4.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C

4.2: 10 - 15 °C

5.1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 25 - 30 °C / 2206.72 - 2942.29 Torr / autoclave

6.1: chloroform / 0.75 h / -45 - -35 °C

With dmap; n-butyllithium; D-tartaric acid; hydrogen; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; dichloromethane; chloroform; isopropyl alcohol; acetonitrile;

Reference yield:

: (+/-)-N,N-diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropylamine

: 1390644-39-9
(R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-formylphenyl methacrylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran / 0.75 h / -65 - -55 °C

2.1: D-tartaric acid / isopropyl alcohol / 16 h / 30 - 35 °C

2.2: 10 - 15 °C

3.1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 25 - 30 °C / 2206.72 - 2942.29 Torr / autoclave

4.1: chloroform / 0.75 h / -45 - -35 °C

With n-butyllithium; D-tartaric acid; hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; chloroform; isopropyl alcohol;