(E)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-acrylic acid

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Chemical Name:(E)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-acrylic acid
CAS No.:948558-82-5
Molecular Formula:C₂₀H₁₇Cl₂N₃O₃
Molecular Weight:418.279
Hs Code.:

Synonyms:(E)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-acrylic acid

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Chemical Property of (E)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-acrylic acid

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Technology Process of (E)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-acrylic acid

There total 1 articles about (E)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 948558-79-0
(S)-6-[3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridine-3-carbaldehyde

: 372-09-8
cyanoacetic acid

: 948558-82-5
(E)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-acrylic acid

Guidance literature:: With piperidine; In toluene; Heating / reflux;

Reference yield:

: 948558-82-5
(E)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-acrylic acid

: (R)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-propionic acid

: (S)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-propionic acid

Guidance literature:: (E)-2-cyano-3-{6-[(S)-3-(2,6-dichloro-4-methyl-phenoxy)-pyrrolidin-1-yl]-pyridin-3-yl}-acrylic acid; With sodium tetrahydroborate; sodium hydrogencarbonate; In methanol; water; at 0 - 20 ℃; for 4h;

With hydrogenchloride; In methanol; water; at 20 ℃; pH=4;