tert-butyl (3-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)carbamate

Base Information

Chemical Name:tert-butyl (3-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)carbamate
CAS No.:1392497-95-8
Molecular Formula:C₂₁H₃₁N₅O₅
Molecular Weight:433.508
Hs Code.:

Synonyms:tert-butyl (3-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)carbamate

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Chemical Property of tert-butyl (3-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)carbamate

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Technology Process of tert-butyl (3-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)carbamate

There total 3 articles about tert-butyl (3-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 21253-58-7
2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine

: 1392497-95-8
tert-butyl (3-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)carbamate

Guidance literature:: With caesium carbonate; sodium iodide; In N,N-dimethyl-formamide; at 75 ℃; for 2h;
DOI:10.1039/c5cc05208d

Reference yield:

: 21253-58-7
2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine

: 167479-01-8
tert-butyl (3-iodopropyl)carbamate

: 1392497-95-8
tert-butyl (3-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)carbamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 70 ℃; for 7h;
DOI:10.1021/ja303374p

Reference yield:

: 738-70-5
5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine

: 1392497-95-8
tert-butyl (3-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / 0.33 h / 90 - 100 °C / Inert atmosphere

2: sodium iodide; caesium carbonate / N,N-dimethyl-formamide / 2 h / 75 °C

With hydrogen bromide; caesium carbonate; sodium iodide; In N,N-dimethyl-formamide;
DOI:10.1039/c5cc05208d