C₁₇H₁₆ClF₃N₂O₂

Base Information

• Chemical Name: C₁₇H₁₆ClF₃N₂O₂
• CAS No.: 1565870-86-1
• Molecular Formula: C₁₇H₁₆ClF₃N₂O₂
• Molecular Weight: 372.774
• Mol file: 1565870-86-1.mol

Synonyms:C₁₇H₁₆ClF₃N₂O₂

Chemical Property of C₁₇H₁₆ClF₃N₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₁₇H₁₆ClF₃N₂O₂

There total 1 articles about C₁₇H₁₆ClF₃N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

p-trifluoromethylphenyl bromide (402-43-7) + tert-butyl (4-chloropyridin-3-yl)carbamate (1068976-14-6) → C17H16ClF3N2O2 (1565870-86-1)

Guidance literature:

With potassium phosphate; copper(l) iodide; trans-1,2-Diaminocyclohexane; In 1,4-dioxane; at 110 ℃; for 22h; Schlenk technique; Inert atmosphere;

DOI:10.1021/jo500064j

Reference yield: 89.0%

C17H16ClF3N2O2 (1565870-86-1) → C12H8ClF3N2 (1565870-63-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jo500064j

Reference yield:

C17H16ClF3N2O2 (1565870-86-1) → 3-(4-(trifluoromethyl)phenyl)-3H-imidazo[4,5-c]pyridine (1565870-73-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: potassium phosphate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / tert-butyl alcohol / 6 h / 110 °C / Schlenk technique; Inert atmosphere

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; trifluoroacetic acid; In dichloromethane; tert-butyl alcohol;

DOI:10.1021/jo500064j

upstream raw materials:

p-trifluoromethylphenyl bromide

tert-butyl (4-chloropyridin-3-yl)carbamate

Downstream raw materials:

C₁₂H₈ClF₃N₂

3-(4-(trifluoromethyl)phenyl)-3H-imidazo[4,5-c]pyridine

Refernces