1068976-14-6 Usage
Description
3-Boc-amino-4-chloropyridine, with the molecular formula C10H11ClN2O2, is a heterocyclic compound that features both a pyridine and a chloropyridine group. It is recognized for its role as an intermediate in the synthesis of various pharmaceuticals, particularly in the development of antiviral and anticancer drugs. Its unique structure allows it to potentially modify the activity of biological molecules, making it a valuable asset in medicinal chemistry. However, due to its potential harmful effects if mishandled, careful use is paramount.
Uses
Used in Pharmaceutical Industry:
3-Boc-amino-4-chloropyridine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of antiviral and anticancer drugs. Its incorporation into these medications aids in enhancing their therapeutic effects against viral infections and cancerous cells.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-Boc-amino-4-chloropyridine is utilized as a research compound to explore and develop new chemical entities. Its capacity to modify the activity of biological molecules makes it instrumental in the advancement of novel therapeutic agents and drug discovery processes.
Used in Drug Development:
3-Boc-amino-4-chloropyridine is employed as a component in the research and development of new drugs, where its unique properties can be leveraged to improve the efficacy and safety profiles of medications. Its role in drug development is crucial for creating innovative treatments that address unmet medical needs.
Check Digit Verification of cas no
The CAS Registry Mumber 1068976-14-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,8,9,7 and 6 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1068976-14:
(9*1)+(8*0)+(7*6)+(6*8)+(5*9)+(4*7)+(3*6)+(2*1)+(1*4)=196
196 % 10 = 6
So 1068976-14-6 is a valid CAS Registry Number.
1068976-14-6Relevant articles and documents
Synthesis of N-Substituted 3-Amino-4-halopyridines: A Sequential Boc-Removal/Reductive Amination Mediated by Br?nsted and Lewis Acids
Wilhelmsen, Christopher A.,Dixon, Alexandre D.C.,Chisholm, John D.,Clark, Daniel A.
, p. 1634 - 1642 (2018/02/09)
N-Substituted 3-amino-4-halopyridines are valuable synthetic intermediates, as they readily provide access to imidazopyridines and similar heterocyclic systems. The direct synthesis of N-substituted 3-amino-4-halopyridines is problematic, as reductive aminations and base-promoted alkylations are difficult in these systems. A high yielding deprotection/alkylation protocol mediated by trifluoroacetic acid and trimethylsilyl trifluoromethanesulfonate is described, providing access to a wide scope of N-substituted 3-amino-4-halopyridines. This protocol furnishes many reaction products in high purity without chromatography. Similar reductive amination conditions were also established for deactivated anilines.
