5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

Base Information

• Chemical Name: 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride
• CAS No.: 116091-64-6
• Molecular Formula: C₁₈H₂₄N₂O₃S*ClH
• Molecular Weight: 384.927
• Mol file: 116091-64-6.mol

Synonyms:5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

Chemical Property of 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

Chemical Property:

• Melting Point: 232-236 °C

Purity/Quality:

99% ^*data from raw suppliers

R,R-2-Methoxy-5-[2-(1-phenylethylamino)-propyl]BenzeneSulfonamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: R,R-2-Methoxy-5-[2-(1-phenylethylamino)-propyl] Benzene Sulfonamide Hydrochloride is an impurity and metabolite of the a1-adrenergic blocking agent Tamsulosin (T006350). It is optically active.

Technology Process of 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

There total 1 articles about 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.7%

(R)-1-phenyl-ethyl-amine (3886-69-9) + 2-methoxy-5-(2-oxopropyl)benzenesulfonamide (116091-63-5) → 5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride (116091-64-6)

Guidance literature:

(R)-1-phenyl-ethyl-amine; 2-methoxy-5-(2-oxopropyl)benzenesulfonamide; With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 30 - 35 ℃; for 16h;

With hydrogenchloride; In water; for 0.5h;

Reference yield: 95.0%

5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride (116091-64-6) → (R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide hydrochloride (86225-65-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; under 760.051 Torr;

Reference yield: 80.0%

5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride (116091-64-6) → 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide (112101-81-2)

Guidance literature:

5-[[(2R)-2-[(1R)-N-(1-methylbenzyl)]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride; pyrographite; In methanol; at 20 ℃; for 0.5h;

With hydrogen; palladium 10% on activated carbon; In methanol; at 60 - 65 ℃; under 2942.29 - 3677.86 Torr;

With ammonia; In water;

upstream raw materials:

(R)-1-phenyl-ethyl-amine

2-methoxy-5-(2-oxopropyl)benzenesulfonamide

Downstream raw materials:

R,R-2-hydroxy-5-[2-(1-phenylethylamino)propyl]benzenesulfonamide

(R)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide hydrochloride

5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide

(R)-tamsulosin

Refernces

• 1、 -. "A METHOD OF PREPARATION OF (R)-(-)-5(2-AMINOPROPYL)-2-METHOXYBENZENESULFONAMIDE". Page/Page column 10. . Retrieved 2008/06/13.
• 2、 -. "TAMSULOSIN DERIVATIVE". Page/Page column 17-18. . Retrieved 2008/06/13.