112101-81-2 Usage
Description
R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide, also known as R-MAB-203, is a chemical compound with potential therapeutic applications. It is a potent and selective inhibitor of the enzyme carbonic anhydrase IX, which is overexpressed in various cancers. By inhibiting the activity of this enzyme, R-MAB-203 has the potential to suppress tumor growth and metastasis. This chemical has also shown promise in the treatment of hypoxic tumors, which are resistant to traditional chemotherapy and radiation therapy. Research on R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide is ongoing, and it may have future applications in cancer treatment and other medical fields.
Uses
Used in Cancer Treatment:
R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide is used as an inhibitor of carbonic anhydrase IX for its potential to suppress tumor growth and metastasis in various cancers. Its selectivity for the overexpressed enzyme in cancer cells makes it a promising candidate for targeted cancer therapy.
Used in Hypoxic Tumor Treatment:
R-MAB-203 is used as a therapeutic agent for hypoxic tumors, which are resistant to traditional chemotherapy and radiation therapy. Its ability to inhibit carbonic anhydrase IX may help overcome the resistance of these tumors to conventional treatments.
Used in Pharmaceutical Industry:
R-(-)-5-(2-Amino-propyl)-2-methoxy-benzenesulfonamide is used as a research compound in the pharmaceutical industry for the development of new cancer treatments. Its potential applications in cancer therapy and other medical fields are currently being explored through ongoing research.
Check Digit Verification of cas no
The CAS Registry Mumber 112101-81-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,1,0 and 1 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 112101-81:
(8*1)+(7*1)+(6*2)+(5*1)+(4*0)+(3*1)+(2*8)+(1*1)=52
52 % 10 = 2
So 112101-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H13NO4S/c1-7(12)5-8-3-4-9(15-2)10(6-8)16(11,13)14/h3-4,6H,5H2,1-2H3,(H2,11,13,14)
112101-81-2Relevant articles and documents
NOVEL PROCESS FOR THE SYNTHESIS OF ENANTIOMERICALLY PURE 2-METHOXY-5-[(2R)-2-(4-ALKYLPIPERAZIN-L-YL)PROPYL]-BENZENESULFONAMIDE
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Page/Page column 7, (2012/08/08)
Where R is C1-C3 alkyl, alkenyl A novel process for synthesis of compound of Formula 1 comprising steroselective catalytic reduction of compound of Formula IV under hydrogen gas pressure to obtain an intermediate compound of Formula II, which on coupling in presence of coupling agent and base in presence of organic solvent to obtain compound of Formula X, Formula X on reacting with deprotecting agent in presence of organic solvent results in formation of compound of Formula XI, condensation of Formula XI with alkyl halide results in formation of compound of Formula I.
Improved process for the preparation of tamsulosin hydrochloride
Reddy, A. Veera,Bhaskara Rao, S. Udaya,Narasimha, G. Lakshmi,Dubey
experimental part, p. 1451 - 1456 (2009/09/25)
Ellman's sulfinamide reagent is used in asymmetric synthesis of Tamsulosin hydrochloride. The enantiomeric ratio achieved is 87:13. The crystallization of the same with dibenzoyl tartarate afforded the product 2 with 99.5% ee.
Assymetric formal synthesis of (-)-formoterol and (-)-tamsulosin
Kim, Yongeun,Kang, Lae-Sung,Ha, Hyun-Joon,Ko, Seung Whan,Lee, Won Koo
, p. 2243 - 2248 (2008/09/17)
Biologically important (2R)-2-amino-3-phenylpropanes consisted in commercial drugs including (R,R)-formoterol, and (R)-tamsulosin were prepared from chiral (2R)-aziridine-2-carboxylate without any chromatographic separation. Key reactions include regio- and stereoselective ring opening reaction of aziridin-2-yl-phenylmethanol and subsequent cyclization toward enantiopure 4,5-disubastitued oxazolidin-2-ones as synthetic intermediates.