(3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Base Information

Chemical Name:(3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone
CAS No.:213619-60-4
Molecular Formula:C₁₉H₂₆N₂O₃
Molecular Weight:330.427
Hs Code.:

Synonyms:(3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Suppliers and Price of (3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

There total 11 articles about (3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (S)-2-Amino-N-((R)-1-benzoyl-2-methyl-propyl)-propionamide; hydrochloride

: 213619-60-4
(3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

: (3R,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Guidance literature:: (S)-2-Amino-N-((R)-1-benzoyl-2-methyl-propyl)-propionamide; hydrochloride; With potassium carbonate; In water;

di-tert-butyl dicarbonate; With dmap; In tetrahydrofuran; at 0 ℃; for 1.5h;
DOI:10.1002/1099-0690(200008)2000:15<2809::AID-EJOC2809>3.0.CO;2-X

Reference yield:

: 22838-58-0
Boc-D-Val-OH

: 213619-60-4
(3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Guidance literature:: Multi-step reaction with 6 steps

1.1: Et₃N; N,N,N',N'-tetramethyl-O-(benzotriazol-1-yl)uronium BF₄ / acetonitrile / 20 °C

2.1: tetrahydrofuran / 24 h / 20 °C

3.1: HCl(g) / ethyl acetate / 0.5 h / 20 °C

4.1: 95 percent / Et₃N / 3 h / 20 °C

5.1: HCl(g) / ethyl acetate / 1 h

6.1: K₂CO₃ / H₂O

6.2: 4-(dimethylamino)pyridine / tetrahydrofuran / 1.5 h / 0 °C

With hydrogenchloride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; water; ethyl acetate; acetonitrile; 1.1: Acylation / 2.1: Grignard reaction / 3.1: Hydrolysis / 4.1: Acylation / 5.1: deprotection / 6.1: Cyclization / 6.2: Acylation;
DOI:10.1002/1099-0690(200008)2000:15<2809::AID-EJOC2809>3.0.CO;2-X

Reference yield:

: 640-68-6,25609-85-2,7004-03-7,921-10-8
D-Val-OH

: 213619-60-4
(3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaHCO₃ / dioxane; H₂O / 12 h / Heating

2.1: Et₃N; N,N,N',N'-tetramethyl-O-(benzotriazol-1-yl)uronium BF₄ / acetonitrile / 20 °C

3.1: tetrahydrofuran / 24 h / 20 °C

4.1: HCl(g) / ethyl acetate / 0.5 h / 20 °C

5.1: 95 percent / Et₃N / 3 h / 20 °C

6.1: HCl(g) / ethyl acetate / 1 h

7.1: K₂CO₃ / H₂O

7.2: 4-(dimethylamino)pyridine / tetrahydrofuran / 1.5 h / 0 °C

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; acetonitrile; 1.1: Acylation / 2.1: Acylation / 3.1: Grignard reaction / 4.1: Hydrolysis / 5.1: Acylation / 6.1: deprotection / 7.1: Cyclization / 7.2: Acylation;
DOI:10.1002/1099-0690(200008)2000:15<2809::AID-EJOC2809>3.0.CO;2-X