(3S,6R)-3-allyl-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Base Information

• Chemical Name: (3S,6R)-3-allyl-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone
• CAS No.: 213619-63-7
• Molecular Formula: C₂₂H₃₀N₂O₃
• Molecular Weight: 370.492

Synonyms:(3S,6R)-3-allyl-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Chemical Property of (3S,6R)-3-allyl-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3S,6R)-3-allyl-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

There total 14 articles about (3S,6R)-3-allyl-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

allyl iodid (556-56-9) + (3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone (213619-60-4) → (3S,6R)-3-allyl-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone (213619-63-7) + (6R)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone C-3 dimer

Guidance literature:

With tetrabutyl-ammonium chloride; potassium carbonate; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1002/1099-0690(200008)2000:15<2809::AID-EJOC2809>3.0.CO;2-X

Reference yield: 77.0%

3-chloroprop-1-ene (107-05-1) + (3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone (213619-60-4) → (3S,6R)-3-allyl-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone (213619-63-7) + (6R)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone C-3 dimer

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium iodide; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 20h;

DOI:10.1002/1099-0690(200008)2000:15<2809::AID-EJOC2809>3.0.CO;2-X

Reference yield: 75.0%

allyl methyl carbonate (35466-83-2) + (3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone (213619-60-4) → (3S,6R)-3-allyl-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone (213619-63-7)

Guidance literature:

Pd(PPh₃)(OAc)2; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1002/1099-0690(200008)2000:15<2809::AID-EJOC2809>3.0.CO;2-X

upstream raw materials:

allyl methyl carbonate

allyl iodid

(3S,6R)-N-1-Boc-6-isopropyl-3-methyl-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

allyl bromide

Downstream raw materials:

(S)-α-allylalanine

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