2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde

Base Information

• Chemical Name: 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde
• CAS No.: 126706-12-5
• Molecular Formula: C₂₀H₁₆F₂N₂O
• Molecular Weight: 338.357
• Mol file: 126706-12-5.mol

Synonyms:2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde

Chemical Property of 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde

There total 1 articles about 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-methanol (122253-18-3) → 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde (126706-12-5)

Guidance literature:

With pyridine; chromium(VI) oxide; In dichloromethane; at 0 ℃;

DOI:10.1016/S0040-4039(01)93462-8

Reference yield: 75.0%

ethyl 2-(diphenylphosphoryl)-2-fluoroacetate (126706-15-8) + 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde (126706-12-5) → (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-acrylic acid ethyl ester (126706-16-9)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1016/S0040-4039(01)93462-8

Reference yield: 72.0%

2-(O,O-diethyl-phosphono)-2-fluoro-acetonitrile (109626-99-5) + 2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde (126706-12-5) → (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-acrylonitrile (126706-09-0,126706-13-6)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane; at 20 ℃; for 2h;

DOI:10.1016/S0040-4039(01)93462-8

upstream raw materials:

[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-methanol

Downstream raw materials:

(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-acrylonitrile

(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-acrylic acid ethyl ester

(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol

(Z)-(S)-5-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-4-fluoro-3-hydroxy-pent-4-enoic acid methyl ester