(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol

Base Information

• Chemical Name: (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol
• CAS No.: 126706-17-0
• Molecular Formula: C₂₂H₁₉F₃N₂O
• Molecular Weight: 384.401
• Mol file: 126706-17-0.mol

Synonyms:(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol

Chemical Property of (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol

There total 3 articles about (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-acrylic acid ethyl ester (126706-16-9) → (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol (126706-17-0)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(01)93462-8

Reference yield:

[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-methanol (122253-18-3) → (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol (126706-17-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / CrO₃, pyridine / CH₂Cl₂ / 0 °C

2: 75 percent / BuLi / tetrahydrofuran / 0.5 h / 0 °C

3: 90 percent / diisobutylaluminium hydride / CH₂Cl₂ / 2 h / 0 °C

With pyridine; chromium(VI) oxide; n-butyllithium; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(01)93462-8

Reference yield:

2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde (126706-12-5) → (Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-prop-2-en-1-ol (126706-17-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / BuLi / tetrahydrofuran / 0.5 h / 0 °C

2: 90 percent / diisobutylaluminium hydride / CH₂Cl₂ / 2 h / 0 °C

With n-butyllithium; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4039(01)93462-8

upstream raw materials:

(Z)-3-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-2-fluoro-acrylic acid ethyl ester

[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-methanol

2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carbaldehyde

Downstream raw materials:

Sodium; (Z)-(3R,5S)-7-[2,4-bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoate

(Z)-(S)-5-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-4-fluoro-3-hydroxy-pent-4-enoic acid (S)-2-hydroxy-1,2,2-triphenyl-ethyl ester

(Z)-(3R,5S)-7-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-3,5-dihydroxy-hept-6-enoic acid tert-butyl ester

(Z)-(S)-7-[2,4-Bis-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-6-fluoro-5-hydroxy-3-oxo-hept-6-enoic acid tert-butyl ester