(1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-7-hydroxy-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Base Information

Chemical Name:(1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-7-hydroxy-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane
CAS No.:956484-96-1
Molecular Formula:C₃₂H₃₂N₂O₈
Molecular Weight:572.615
Hs Code.:

Synonyms:(1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-7-hydroxy-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

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Chemical Property of (1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-7-hydroxy-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

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Technology Process of (1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-7-hydroxy-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

There total 7 articles about (1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-7-hydroxy-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: C₃₇H₄₄N₂O₈Si

: 956484-96-1
(1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-7-hydroxy-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: With triethylamine tris(hydrogen fluoride); triethylamine; In tetrahydrofuran; at 20 ℃; for 48h;

Reference yield: 90.0%

: 956484-95-0
(1R,3R,4R,7S)-7-(tert-butyldimethylsilyloxy)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

: 956484-96-1
(1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-7-hydroxy-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1021/jm101207e

Reference yield:

: C₂₁H₂₆N₂O₆

: 956484-96-1
(1R,3R,4R,7S)-1-[1-(R)-(4,4'-dimethoxytrityloxy)ethyl]-7-hydroxy-3-(uracil-1-yl)-2,5-dioxabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 16 h

2: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C

3: potassium carbonate; methanol / 16 h / 20 °C

4: 2,6-dimethylpyridine / pyridine / 48 h / 45 °C

5: triethylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 48 h / 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; methanol; hydrogen; potassium carbonate; triethylamine tris(hydrogen fluoride); triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide;