C₆₉H₈₃Cl₃N₄O₁₆SSi

Base Information

• Chemical Name: C₆₉H₈₃Cl₃N₄O₁₆SSi
• CAS No.: 854022-33-6
• Molecular Formula: C₆₉H₈₃Cl₃N₄O₁₆SSi
• Molecular Weight: 1390.95
• Mol file: 854022-33-6.mol

Synonyms:C₆₉H₈₃Cl₃N₄O₁₆SSi

Chemical Property of C₆₉H₈₃Cl₃N₄O₁₆SSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₉H₈₃Cl₃N₄O₁₆SSi

There total 28 articles about C₆₉H₈₃Cl₃N₄O₁₆SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(R)-N-Troc-S-tris(4-methoxyphenyl)methyl cystein + {2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester (854022-31-4) → C69H83Cl3N4O16SSi (854022-33-6)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

DOI:10.1021/jo050408k

Reference yield:

{2-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-phenyl]-1-formyl-ethyl}-carbamic acid allyl ester (854022-39-2) → C69H83Cl3N4O16SSi (854022-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: molecular sieves 3 Angstroem / toluene / 40 °C

2: 590.0 mg / BF₃*OEt₂ / CH₂Cl₂ / -30 °C

3: 74 percent / DMAP; EDCl / CH₂Cl₂ / 20 °C

With dmap; 3 A molecular sieve; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; toluene;

DOI:10.1021/jo050408k

Reference yield:

(S)-allyl 1-hydroxy-3-(3-tert-butyldimethylsilyloxy-4-methoxy-5-methylphenyl)propan-2-ylcarbamate (854022-23-4) → C69H83Cl3N4O16SSi (854022-33-6)

Guidance literature:

Multi-step reaction with 4 steps

1: DMSO; oxalyl chloride; triethylamine / CH₂Cl₂ / -78 - 0 °C

2: molecular sieves 3 Angstroem / toluene / 40 °C

3: 590.0 mg / BF₃*OEt₂ / CH₂Cl₂ / -30 °C

4: 74 percent / DMAP; EDCl / CH₂Cl₂ / 20 °C

With dmap; oxalyl dichloride; 3 A molecular sieve; boron trifluoride diethyl etherate; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; toluene; 1: Swern oxidation;

DOI:10.1021/jo050408k

upstream raw materials:

{2-(11-allyloxy-7-hydroxymethyl-2,2,12-trimethyl-4,5,7,10-tetrahydro-1,3,15,17-tetraoxa-6-aza-cyclopenta[a]phenanthren-6-yl)-1-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-benzyl]-2-cyano-ethyl}-carbamic acid allyl ester

{2-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-phenyl]-1-formyl-ethyl}-carbamic acid allyl ester

(S)-allyl 1-hydroxy-3-(3-tert-butyldimethylsilyloxy-4-methoxy-5-methylphenyl)propan-2-ylcarbamate

[2-[3-(tert-butyl-dimethyl-silanyloxy)-4-methoxy-5-methyl-phenyl]-1-(tert-butyl-dimethyl-silanyloxymethyl)-ethyl]-carbamic acid allyl ester