1-chloro-1-(2-phenylhydrazono)acetone

Base Information

• Chemical Name: 1-chloro-1-(2-phenylhydrazono)acetone
• CAS No.: 18440-58-9
• Molecular Formula: C9H9 Cl N2 O
• Molecular Weight: 196.636
• Hs Code.: 2928000090
• Mol file: 18440-58-9.mol

Synonyms:Pyruvoylchloride, 1-(phenylhydrazone) (8CI); 1-Chloro-1-(phenylhydrazono)-2-propanone;2-Oxo-N-phenylpropanehydrazonoyl chloride;Acetyl(phenylhydrazono)chloromethane; N-Phenylacetohydrazonoyl chloride; a-Chloro-a-(acetylcarbonyl)phenylhydrazone

Chemical Property of 1-chloro-1-(2-phenylhydrazono)acetone

Chemical Property:

• Vapor Pressure: 0.00187mmHg at 25°C
• Refractive Index: 1.557
• Boiling Point: 292.1°C at 760 mmHg
• PKA: 10.55±0.10(Predicted)
• Flash Point: 130.4°C
• PSA: 41.46000
• Density: 1.19g/cm³
• LogP: 2.31280

Purity/Quality:

97% ^*data from raw suppliers

2-Oxo-N-phenylpropanehydrazonoyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-chloro-1-(2-phenylhydrazono)acetone

There total 11 articles about 1-chloro-1-(2-phenylhydrazono)acetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

aniline (62-53-3) + 3-chloropentane-2,4-dione (1694-29-7) → 1-(N-phenylhydrazono)-1-chloropropanone (18440-58-9,1017827-91-6)

Guidance literature:

3-chloropentane-2,4-dione; With sodium acetate; In ethanol; at 0 ℃; for 0.25h;

aniline; With hydrogenchloride; sodium nitrite; In ethanol; water; at 0 - 5 ℃; for 2h;

DOI:10.1016/j.bioorg.2020.104134

Reference yield:

benzene diazonium chloride (100-34-5) + 3-chloropentane-2,4-dione (1694-29-7) → 1-(N-phenylhydrazono)-1-chloropropanone (18440-58-9,1017827-91-6)

Guidance literature:

With ethanol; potassium acetate;

Reference yield:

benzene diazonium chloride (100-34-5) + 3-chloropentane-2,4-dione (1694-29-7) → 1-chloro-1-(phenylhydrazono)propanone (18440-58-9,1017827-91-6)

Guidance literature:

DOI:10.3987/com-99-8829

upstream raw materials:

benzene diazonium chloride

3-chloropentane-2,4-dione

aniline

benzenediazonium

Downstream raw materials:

1-(6-Furan-2-yl-2-methyl-5-phenyl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-yl)-ethanone

1-(2-Methyl-5-phenyl-6-thiophen-2-yl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-yl)-ethanone

1-(1-Phenyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-3-yl)-ethanone

5-acetyl-2,3-dihydro-3-phenyl-2-<(thiobenzoyl)methylene>-1,3,4-thiadiazole