Technology Process of (3-(4-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)propyl)phosphonic acid
There total 7 articles about (3-(4-((1H-1,2,4-triazol-1-yl)methyl)-N-hydroxybenzamido)-1-(3,4-dichlorophenyl)propyl)phosphonic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trimethylsilyl bromide;
In
dichloromethane;
at 20 ℃;
for 20h;
Inert atmosphere;
DOI:10.1021/jm4006498
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine; C5H9O6P / ethyl acetate / 1 h / 20 °C
2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 760.05 Torr
3: trimethylsilyl bromide / dichloromethane / 20 h / 20 °C / Inert atmosphere
With
trimethylsilyl bromide; palladium 10% on activated carbon; C5H9O6P; hydrogen; triethylamine;
In
methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm4006498
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: palladium diacetate; p-benzoquinone; 2.9-dimethyl-1,10-phenanthroline / 100 °C / Microwave irradiation
2.1: phenol / 100 °C
2.2: 100 °C
3.1: pyridine / ethanol / 20 °C
3.2: 20 °C
4.1: triethylamine; C5H9O6P / ethyl acetate / 1 h / 20 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 760.05 Torr
6.1: trimethylsilyl bromide / dichloromethane / 20 h / 20 °C / Inert atmosphere
With
pyridine; 2.9-dimethyl-1,10-phenanthroline; trimethylsilyl bromide; palladium 10% on activated carbon; C5H9O6P; hydrogen; palladium diacetate; triethylamine; p-benzoquinone; phenol;
In
methanol; ethanol; dichloromethane; ethyl acetate;
1.1: |Heck Reaction;
DOI:10.1021/jm4006498
