Technology Process of 4-Chloro-7-nitroquinoline
There total 14 articles about 4-Chloro-7-nitroquinoline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trichlorophosphate;
at 110 ℃;
for 0.75h;
DOI:10.1021/jm9902180
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 96 percent / 1 h / 90 °C
2.1: 31 percent / diphenyl ether / 0.5 h / 255 °C
3.1: 64 percent / 10 percent aq. NaOH / 0.5 h / 100 °C
4.1: NH4OH; AgNO3 / H2O / 0.5 h / Heating
4.2: 34 percent / diphenyl ether / 1 h / 255 °C
5.1: 98 percent / phosphorus oxychloride / 0.75 h / 110 °C
With
ammonium hydroxide; sodium hydroxide; silver nitrate; trichlorophosphate;
In
diphenylether; water;
1.1: Substitution / 2.1: Cyclization / 3.1: Hydrolysis / 4.1: Metallation / 4.2: Decarboxylation / 5.1: Chlorination;
DOI:10.1021/jm9902180
