H-D-Ser-(CH₂Ph)-Gly-Phe-Leu-Thr-OCH₂Ph*F₃CCOOH

Base Information

Chemical Name:H-D-Ser-(CH₂Ph)-Gly-Phe-Leu-Thr-OCH₂Ph*F₃CCOOH
CAS No.:115160-78-6
Molecular Formula:C₂HF₃O₂*C₃₈H₄₉N₅O₈
Molecular Weight:817.86
Hs Code.:

H-D-Ser-(CH<sub>2</sub>Ph)-Gly-Phe-Leu-Thr-OCH<sub>2</sub>Ph*F<sub>3</sub>CCOOH

Synonyms:H-D-Ser-(CH₂Ph)-Gly-Phe-Leu-Thr-OCH₂Ph*F₃CCOOH

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of H-D-Ser-(CH₂Ph)-Gly-Phe-Leu-Thr-OCH₂Ph*F₃CCOOH

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Technology Process of H-D-Ser-(CH₂Ph)-Gly-Phe-Leu-Thr-OCH₂Ph*F₃CCOOH

There total 2 articles about H-D-Ser-(CH₂Ph)-Gly-Phe-Leu-Thr-OCH₂Ph*F₃CCOOH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 115160-76-4
N-(tert-butyloxycarbonyl)-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

: 76-05-1
trifluoroacetic acid

: 115160-78-6
H-D-Ser-(CH₂Ph)-Gly-Phe-Leu-Thr-OCH₂Ph*F₃CCOOH

Guidance literature:: DOI:10.1021/jm00118a005

Reference yield:

: 47173-80-8
N-Boc-D-serine(Bzl)-OH

: 115160-78-6
H-D-Ser-(CH₂Ph)-Gly-Phe-Leu-Thr-OCH₂Ph*F₃CCOOH

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / 1-hydroxybenzotriazole / triethylamine; CHCl₃; tetrahydrofuran / 0 deg C, 1 h; overnight

2: 87 percent

With benzotriazol-1-ol; In tetrahydrofuran; chloroform; triethylamine;
DOI:10.1021/jm00118a005

Reference yield: 70.0%

: 3978-80-1
Boc-Tyr-OH

: 115160-78-6
H-D-Ser-(CH₂Ph)-Gly-Phe-Leu-Thr-OCH₂Ph*F₃CCOOH

: 115141-33-8
N-(tert-butyloxycarbonyl)-L-tyrosyl-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; triethylamine; 0 deg C, 1 h; overnight;
DOI:10.1021/jm00118a005