N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

Base Information

Chemical Name:N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide
CAS No.:1257229-97-2
Molecular Formula:C₂₂H₂₃F₇N₄O₄S₂
Molecular Weight:604.57
Hs Code.:

N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

Synonyms:N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

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Chemical Property of N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

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Technology Process of N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

There total 1 articles about N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257229-36-9
3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1257229-97-2
N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

Guidance literature:: at 20 ℃; for 0.333333h;

Reference yield: 75.0%

: 1257229-97-2
N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

: 2,2,2-trifluoro-1-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-1-(4H-1,2,4-triazol-3-yl)ethanol

Guidance literature:: With acetic acid; hydrazine; at 20 ℃; for 1h;
DOI:10.1021/ml300352x

Reference yield:

: 1257229-97-2
N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide

: 1257229-57-4
2,2,2-trifluoro-1-[5-({(2R)-4-[4-fluoro-2-(trifluoromethyl)phenyl]-2-methylpiperazin-1-yl}sulfonyl)-2-thienyl]-1-(4H-1,2,4-triazol-3-yl)ethanol

Guidance literature:: N-((dimethylamino)methylene)-3,3,3-trifluoro-2-(5-(((R)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperazin-1-yl)sulfonyl)thiophen-2-yl)-2-hydroxypropanamide; With acetic acid; hydrazine; at 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; ethyl acetate;