2-(((3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile

Base Information

• Chemical Name: 2-(((3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile
• CAS No.: 1598411-35-8
• Molecular Formula: C₁₄H₉F₆N₃S
• Molecular Weight: 365.302
• Mol file: 1598411-35-8.mol

Synonyms:2-(((3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile

Chemical Property of 2-(((3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-(((3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile

There total 1 articles about 2-(((3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

[Bis(methylthio)methylene]malononitrile (5147-80-8) + 3,5-bis-trifluoromethylbenzylamine (85068-29-7) → 2-(((3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile (1598411-35-8)

Guidance literature:

In tetrahydrofuran; for 23h; stereoselective reaction; Reflux; Green chemistry;

DOI:10.1016/j.tetlet.2014.03.042

Reference yield: 51.0%

2-(((3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile (1598411-35-8) + 3,5-bis(trifluoromethyl)benzyl bromide (32247-96-4) → 2-((bis(3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile

Guidance literature:

2-(((3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h; Inert atmosphere;

3,5-bis(trifluoromethyl)benzyl bromide; In N,N-dimethyl-formamide; for 22h;

DOI:10.1002/asia.202100487

Reference yield: 51.0%

(1R,2R)-N,N-dimethylcyclohexane-1,2-diamine (320778-92-5) + 2-(((3,5-bis(trifluoromethyl)benzyl)amino)(methylthio)methylene)malononitrile (1598411-35-8) → 2-(((3,5-bis(trifluoromethyl)benzyl)amino)-(((1R,2R)-2-(dimethylamino)cyclohexyl)amino)methylene)malononitrile

Guidance literature:

In tetrahydrofuran; at 85 ℃; for 72h;

DOI:10.1021/acs.joc.9b02553

upstream raw materials:

[Bis(methylthio)methylene]malononitrile

3,5-bis-trifluoromethylbenzylamine

Downstream raw materials:

C₂₃H₂₅F₆N₅O₂