320778-92-5Relevant articles and documents
Synthesis, resolution, and absolute configuration of trans-1-amino-2-dimethylaminocyclohexane
Christoffers, Jens,Schulze, Yvonne,Pickardt, Joachim
, p. 1765 - 1769 (2001)
Racemic trans-1-amino-2-dimethylaminocyclohexane was prepared by aziridine ring opening reaction of 7-azabicyclo[4.1.0]heptane with HNMe2. The resolution of the racemate was accomplished by crystallization as the L-tartrate. The optical purity
The first catalytic, enantioselective aza-Henry reaction of an unactivated cyclic imine
Amarasinghe, Nilupa R.,Todd, Matthew H.,Turner, Peter
supporting information, p. 2954 - 2958,5 (2020/10/15)
The aza-Henry reaction is an efficient route to important chiral, vicinal diamines. Reports of the asymmetric version typically use electron-deficient acyclic imines. We report the first example of a catalytic, asymmetric aza-Henry reaction on an unfunctionalized cyclic imine that gives access to enantiopure diamine derivatives under experimentally straightforward conditions. The stereocentre is established through the initial nitromethane addition to the imine. The scalemic intermediate may be trapped through acylation, then crystallized. Copyright
A simple primary-tertiary diamine-Bronsted acid catalyst for asymmetric direct aldol reactions of linear aliphatic ketones
Luo, Sanzhong,Xu, Hui,Li, Jiuyuan,Zhang, Long,Cheng, Jin-Pei
, p. 3074 - 3075 (2007/10/03)
Compared with the well-explored enamine catalysis with secondary amines, the development of efficient enamine-based primary amine catalysts has remained as an elusive goal until recently. We present herein that a simple chiral primary-tertiary diamine 1d
