benzyl 5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

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Chemical Name:benzyl 5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate
CAS No.:1380316-07-3
Molecular Formula:C₃₈H₄₉N₅O₇
Molecular Weight:687.836
Hs Code.:

benzyl 5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

Synonyms:benzyl 5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

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Chemical Property of benzyl 5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

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Technology Process of benzyl 5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

There total 9 articles about benzyl 5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1380315-99-0
N-(2,4-dimethoxybenzyl)-7-((3aR,4R,6R,6aR)-6-((isopropylamino)methyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 60343-28-4
Benzyl 5-bromovalerate

: 1380316-07-3
benzyl 5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In propiononitrile; at 95 ℃; for 68h;

Reference yield:

: 16754-80-6
4-chloro-7-(β-D-ribofuranosyl)-7H-pyrrolo<2,3-d>pyrimidine

: 1380316-07-3
benzyl 5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 h / 100 - 110 °C

2.1: (1S)-10-camphorsulfonic acid / acetone / 1 h / 20 °C

3.1: triphenylphosphine; diphenyl phosphoryl azide; di-isopropyl azodicarboxylate / tetrahydrofuran / 24.5 h / 0 - 20 °C

4.1: trimethylphosphane / tetrahydrofuran / 20 h / 20 °C

4.2: 2 h / 20 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / propiononitrile / 68 h / 95 °C

With di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; (1S)-10-camphorsulfonic acid; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane; In tetrahydrofuran; 1,2-dichloro-ethane; acetone; propiononitrile; butan-1-ol;

Reference yield:

: 20781-20-8
2,4-Dimethoxybenzylamine

: 1380316-07-3
benzyl 5-((((3aR,4R,6R,6aR)-6-(4-((2,4-dimethoxybenzyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)(isopropyl)amino)pentanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 20 h / 100 - 110 °C

2.1: (1S)-10-camphorsulfonic acid / acetone / 1 h / 20 °C

3.1: triphenylphosphine; diphenyl phosphoryl azide; di-isopropyl azodicarboxylate / tetrahydrofuran / 24.5 h / 0 - 20 °C

4.1: trimethylphosphane / tetrahydrofuran / 20 h / 20 °C

4.2: 2 h / 20 °C

5.1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 1 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; tetra-(n-butyl)ammonium iodide / propiononitrile / 68 h / 95 °C

With di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; (1S)-10-camphorsulfonic acid; tetra-(n-butyl)ammonium iodide; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trimethylphosphane; In tetrahydrofuran; 1,2-dichloro-ethane; acetone; propiononitrile; butan-1-ol;