SNC 83

Base Information

• Chemical Name: SNC 83
• CAS No.: 156727-72-9
• Molecular Formula: C₂₈H₃₉N₃O₂
• Molecular Weight: 449.637
• Mol file: 156727-72-9.mol

Synonyms:SNC 83

Chemical Property of SNC 83

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of SNC 83

There total 12 articles about SNC 83 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

4-[Chloro-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide (186094-10-0) + (+)-(2S,5R)-1-allyl-2,5-dimethylpiperazine (155836-79-6) → SNC 83 (156727-72-9) + SNC 67 (156727-71-8)

Guidance literature:

With potassium carbonate; In acetonitrile; for 72h; Heating;

DOI:10.1021/jm960319n

Reference yield:

(4-methylphenyl)-(3-methoxyphenyl)methanone (82520-37-4) → SNC 83 (156727-72-9)

Guidance literature:

Multi-step reaction with 6 steps

1: 53 percent / KMnO₄ / 2-methyl-propan-2-ol; H₂O / 7.5 h / Heating

2: SOCl₂ / benzene / 3 h / Heating

3: CHCl₃ / 4 h / Ambient temperature

4: 70 percent / NaBH₄ / ethanol; H₂O / 2 h / Heating

5: 11.16 g / 37percent aq. HCl / CHCl₃ / Ambient temperature

6: 24 percent / K₂CO₃ / acetonitrile / 72 h / Heating

With hydrogenchloride; sodium tetrahydroborate; potassium permanganate; thionyl chloride; potassium carbonate; In ethanol; chloroform; water; acetonitrile; tert-butyl alcohol; benzene;

DOI:10.1021/jm960319n

Reference yield:

4-(3-Methoxy-benzoyl)-benzoyl chloride (1027905-05-0) → SNC 83 (156727-72-9)

Guidance literature:

Multi-step reaction with 4 steps

1: CHCl₃ / 4 h / Ambient temperature

2: 70 percent / NaBH₄ / ethanol; H₂O / 2 h / Heating

3: 11.16 g / 37percent aq. HCl / CHCl₃ / Ambient temperature

4: 24 percent / K₂CO₃ / acetonitrile / 72 h / Heating

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; In ethanol; chloroform; water; acetonitrile;

DOI:10.1021/jm960319n

upstream raw materials:

4-[Chloro-(3-methoxy-phenyl)-methyl]-N,N-diethyl-benzamide

(+)-(2S,5R)-1-allyl-2,5-dimethylpiperazine

(4-methylphenyl)-(3-methoxyphenyl)methanone

m-anisoyl chloride

Downstream raw materials:

SNC 85

Refernces

• 1、 Calderon, Silvia N.,Rothman, Richard B.,Porreca, Frank,Flippen-Anderson, Judith L.,McNutt, Robert W.,et al.. "Probes for Narcotic Receptor Mediated Phenomena. 19. Synthesis of (+)-4--N,N-diethylbenzamide (SNC 80): A Highly Selective, Nonpeptide β Opioid Receptor Agonist". . p. 2125 - 2128. Retrieved 2007/10/02.