1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)methyl)azetidine-3-carboxylic acid

Base Information

Chemical Name:1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)methyl)azetidine-3-carboxylic acid
CAS No.:1307810-01-0
Molecular Formula:C₃₀H₃₁FN₂O₃
Molecular Weight:486.586
Hs Code.:

Synonyms:1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)methyl)azetidine-3-carboxylic acid

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Chemical Property of 1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)methyl)azetidine-3-carboxylic acid

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Technology Process of 1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)methyl)azetidine-3-carboxylic acid

There total 13 articles about 1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)methyl)azetidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1307812-92-5
2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazole-7-carbaldehyde

: 36476-78-5
3-azetidinecarboxylic acid

: 1307810-01-0
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)methyl)azetidine-3-carboxylic acid

Guidance literature:: 2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazole-7-carbaldehyde; 3-azetidinecarboxylic acid; With methanol; acetic acid; In 1,2-dichloro-ethane; at 60 ℃; for 1h;

With sodium cyanoborohydride; In methanol; 1,2-dichloro-ethane; at 20 ℃;

Reference yield:

: 3470-50-6
6-Hydroxy-1-tetralone

: 1307810-01-0
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)methyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridine / 4 h / 0 - 20 °C

2.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

4.1: dmap / 1,2-dichloro-benzene / 0.17 h / 180 °C / Microwave irradiation

5.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 18 h / 20 °C

6.1: sodium periodate / water; methanol / 0.5 h / 0 °C

7.1: methanol / acetic acid / 1,2-dichloro-ethane / 1 h / 60 °C

7.2: 20 °C

With pyridine; methanol; dmap; sodium periodate; osmium(VIII) oxide; hydroxylamine hydrochloride; sodium acetate; 4-methylmorpholine N-oxide; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; 1,2-dichloro-benzene;

Reference yield:

: 144464-64-2
5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethanesulfonate

: 1307810-01-0
1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)methyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium chloride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 14 h / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 80 °C

3.1: dmap / 1,2-dichloro-benzene / 0.17 h / 180 °C / Microwave irradiation

4.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tetrahydrofuran / 18 h / 20 °C

5.1: sodium periodate / water; methanol / 0.5 h / 0 °C

6.1: methanol / acetic acid / 1,2-dichloro-ethane / 1 h / 60 °C

6.2: 20 °C

With methanol; dmap; sodium periodate; osmium(VIII) oxide; hydroxylamine hydrochloride; sodium acetate; 4-methylmorpholine N-oxide; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; 1,2-dichloro-benzene;