N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-2-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide

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Chemical Name:N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-2-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide
CAS No.:1018473-10-3
Molecular Formula:C₂₄H₂₁F₃N₆O₂S
Molecular Weight:514.531
Hs Code.:

Synonyms:N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-2-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide

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Chemical Property of N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-2-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide

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Technology Process of N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-2-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide

There total 3 articles about N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-2-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1018473-09-0
N-(4-methyl-3-(2-methyl-4-(6-methylsulfanylpyrimidin-4-yl)-2H-pyrazol-3-ylamino)-phenyl)-3-trifluoromethylbenzamide

: 1018473-10-3
N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-2-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

: 1018473-11-4
4-(6-methylsulfanylpyrimidin-4-yl)-2H-pyrazol-3-ylamine

: 1018473-10-3
N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-2-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 0.5 h

1.2: 20 °C

2.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 150 °C / Irradiation

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

With sodium methylate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 1018473-08-9
2-methyl-4-(6-methylsulfanylpyrimidin-4-yl)-2H-pyrazol-3-ylamine

: 1018473-10-3
N-(3-(4-(6-methanesulfinylpyrimidin-4-yl)-2-methyl-2H-pyrazol-3-ylamino)-4-methylphenyl)-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 150 °C / Irradiation

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 - 20 °C

With caesium carbonate; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;