1-O-benzyl-6-O-[(tert-butyl)(dimethyl)silyl]-2-deoxy-3,4-O-(1-methylethylidene)-D-ribo-hexitol

Base Information

• Chemical Name: 1-O-benzyl-6-O-[(tert-butyl)(dimethyl)silyl]-2-deoxy-3,4-O-(1-methylethylidene)-D-ribo-hexitol
• CAS No.: 1245627-31-9
• Molecular Formula: C₂₂H₃₈O₅Si
• Molecular Weight: 410.626
• Mol file: 1245627-31-9.mol

Synonyms:1-O-benzyl-6-O-[(tert-butyl)(dimethyl)silyl]-2-deoxy-3,4-O-(1-methylethylidene)-D-ribo-hexitol

Chemical Property of 1-O-benzyl-6-O-[(tert-butyl)(dimethyl)silyl]-2-deoxy-3,4-O-(1-methylethylidene)-D-ribo-hexitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-O-benzyl-6-O-[(tert-butyl)(dimethyl)silyl]-2-deoxy-3,4-O-(1-methylethylidene)-D-ribo-hexitol

There total 1 articles about 1-O-benzyl-6-O-[(tert-butyl)(dimethyl)silyl]-2-deoxy-3,4-O-(1-methylethylidene)-D-ribo-hexitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzyl bromide (100-39-0) + (R)-2-((tert-butyldimethylsilyl)oxy)-1-((4R,5S)-5-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol (540510-13-2) → 1-O-benzyl-6-O-[(tert-butyl)(dimethyl)silyl]-2-deoxy-3,4-O-(1-methylethylidene)-D-ribo-hexitol (1245627-31-9)

Guidance literature:

(R)-2-((tert-butyldimethylsilyl)oxy)-1-((4R,5S)-5-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.333333h;

benzyl bromide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 2h; chemoselective reaction;

DOI:10.1002/hlca.200900342

Reference yield: 95.0%

1-O-benzyl-6-O-[(tert-butyl)(dimethyl)silyl]-2-deoxy-3,4-O-(1-methylethylidene)-D-ribo-hexitol (1245627-31-9) → C16H24O5 (1356828-79-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃;

DOI:10.1002/hlca.200900342

upstream raw materials:

benzyl bromide

(R)-2-((tert-butyldimethylsilyl)oxy)-1-((4R,5S)-5-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxolan-4-yl)ethanol

Downstream raw materials:

C₁₆H₂₄O₅