2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)acetic acid

Base Information

Chemical Name:2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)acetic acid
CAS No.:943740-10-1
Molecular Formula:C₄₀H₄₅N₅O₉S
Molecular Weight:771.891
Hs Code.:

Synonyms:2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)acetic acid

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Chemical Property of 2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)acetic acid

Chemical Property:

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Technology Process of 2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)acetic acid

There total 10 articles about 2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 745020-22-8
imidodicarbonic acid 2-(6-amino-1-isoquinolinyl)-1,3-bis(1,1-dimethylethyl)ester

: 943740-09-8
4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid

: 298-12-4
Glyoxilic acid

: 943740-10-1
2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)acetic acid

Guidance literature:: In 1,2-dichloro-ethane; at 100 ℃; Microwave irradiation;
DOI:10.1021/acs.jmedchem.5b00788

Reference yield: 52.0%

: 943740-10-1
2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)acetic acid

Guidance literature:

Reference yield:

: 6628-03-1
4-(4-bromophenyl)-butyryl chloride

: 943740-10-1
2-(1-di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 14 h / 20 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

3: 2,2'-iminobis[ethanol] / diethyl ether; dichloromethane; ethyl acetate; isopropyl alcohol / 20 °C

4: 1,2-dichloro-ethane / 100 °C / Microwave irradiation

With dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; triethylamine; 2,2'-iminobis[ethanol]; In diethyl ether; dichloromethane; dimethyl sulfoxide; ethyl acetate; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.5b00788