4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid

Base Information

Chemical Name:4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid
CAS No.:943740-09-8
Molecular Formula:C₁₉H₂₁BN₂O₅S
Molecular Weight:400.263
Hs Code.:

Synonyms:4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid

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Chemical Property of 4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid

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Technology Process of 4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid

There total 9 articles about 4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 943740-08-7
4-(4-bromophenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide

: 201733-56-4
2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane

: 943740-09-8
4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid

Guidance literature:: 4-(4-bromophenyl)-N-(3-cyano-4-(ethylsulfonyl)phenyl)butanamide; 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane; With potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In dimethyl sulfoxide; at 80 ℃; for 2h;

With 2,2'-iminobis[ethanol]; isopropyl alcohol; In diethyl ether; dichloromethane; ethyl acetate;

Reference yield: 57.0%

: C₂₄H₂₉BN₂O₅S

: 943740-09-8
4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid

Guidance literature:: With 2,2'-iminobis[ethanol]; In diethyl ether; dichloromethane; ethyl acetate; isopropyl alcohol; at 20 ℃;
DOI:10.1021/acs.jmedchem.5b00788

Reference yield:

: 6628-03-1
4-(4-bromophenyl)-butyryl chloride

: 943740-09-8
4-(4-(3-cyano-4-(ethylsulfonyl)phenylamino)-4-oxobutyl)phenylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 14 h / 20 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

3: 2,2'-iminobis[ethanol] / diethyl ether; dichloromethane; ethyl acetate; isopropyl alcohol / 20 °C

With dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; triethylamine; 2,2'-iminobis[ethanol]; In diethyl ether; dichloromethane; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.5b00788