(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-methanesulfonyloxy-2-methyl-butyric acid methyl ester

Base Information

Chemical Name:(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-methanesulfonyloxy-2-methyl-butyric acid methyl ester
CAS No.:77270-00-9
Molecular Formula:C₁₆H₂₄O₇S
Molecular Weight:360.428
Hs Code.:

Synonyms:(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-methanesulfonyloxy-2-methyl-butyric acid methyl ester

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Chemical Property of (R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-methanesulfonyloxy-2-methyl-butyric acid methyl ester

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Technology Process of (R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-methanesulfonyloxy-2-methyl-butyric acid methyl ester

There total 6 articles about (R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-methanesulfonyloxy-2-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 70874-21-4
methyl (R)-(-)-2-methyl-2-<(methylsulfonyl)oxy>-4-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)butanoate

: 77270-00-9
(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-methanesulfonyloxy-2-methyl-butyric acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jo00325a004

Reference yield:

: 77286-98-7
(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid

: 77270-00-9
(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-methanesulfonyloxy-2-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: concd. HCl / 2 h / 90 °C

2: 94.7 percent / p-toluenesulfonic acid monohydrate / 3.75 h / Heating

3: 85 percent / ferric chloride / diethyl ether; methanol; H₂O / 0.5 h

4: 72.5 percent / Et₃N / CH₂Cl₂ / 64 h / 0 °C

5: 100 percent / H₂ / 5percent Pd/C / ethyl acetate

With hydrogenchloride; hydrogen; iron(III) chloride; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo00325a004

Reference yield:

: 77257-11-5
(R)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyric acid

: 77270-00-9
(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-methanesulfonyloxy-2-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / 5percent Pd/C / ethyl acetate

2: concd. HCl / 2 h / 90 °C

3: 94.7 percent / p-toluenesulfonic acid monohydrate / 3.75 h / Heating

4: 85 percent / ferric chloride / diethyl ether; methanol; H₂O / 0.5 h

5: 72.5 percent / Et₃N / CH₂Cl₂ / 64 h / 0 °C

6: 100 percent / H₂ / 5percent Pd/C / ethyl acetate

With hydrogenchloride; hydrogen; iron(III) chloride; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo00325a004