(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid

Base Information

Chemical Name:(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid
CAS No.:77286-98-7
Molecular Formula:C₁₄H₂₀O₅
Molecular Weight:268.31
Hs Code.:

Synonyms:(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid

Suppliers and Price of (R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid

There total 1 articles about (R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 77257-11-5
(R)-2-Hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxo-cyclohexa-1,4-dienyl)-butyric acid

: 77286-98-7
(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jo00325a004

Reference yield:

: 77286-98-7
(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid

: 53101-49-8,53174-06-4,53188-07-1,56305-04-5
(S)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

: 53101-49-8
(R)-trolox

Guidance literature:: With hydrogenchloride; at 90 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1021/jo00325a004

Reference yield:

: 77286-98-7
(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-hydroxy-2-methyl-butyric acid

: 77270-00-9
(R)-4-(2,5-Dihydroxy-3,4,6-trimethyl-phenyl)-2-methanesulfonyloxy-2-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: concd. HCl / 2 h / 90 °C

2: 94.7 percent / p-toluenesulfonic acid monohydrate / 3.75 h / Heating

3: 85 percent / ferric chloride / diethyl ether; methanol; H₂O / 0.5 h

4: 72.5 percent / Et₃N / CH₂Cl₂ / 64 h / 0 °C

5: 100 percent / H₂ / 5percent Pd/C / ethyl acetate

With hydrogenchloride; hydrogen; iron(III) chloride; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; water; ethyl acetate;
DOI:10.1021/jo00325a004