5-(4-Methoxy-phenyl)-2,2-dimethyl-4,5-dihydro-[1,3]dioxepine

Base Information

• Chemical Name: 5-(4-Methoxy-phenyl)-2,2-dimethyl-4,5-dihydro-[1,3]dioxepine
• CAS No.: 153867-11-9
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 153867-11-9.mol

Synonyms:5-(4-Methoxy-phenyl)-2,2-dimethyl-4,5-dihydro-[1,3]dioxepine

Chemical Property of 5-(4-Methoxy-phenyl)-2,2-dimethyl-4,5-dihydro-[1,3]dioxepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-Methoxy-phenyl)-2,2-dimethyl-4,5-dihydro-[1,3]dioxepine

There total 1 articles about 5-(4-Methoxy-phenyl)-2,2-dimethyl-4,5-dihydro-[1,3]dioxepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2,2-dimethyl-4,7-dihydro-1,3-dioxepin (1003-83-4) + para-iodoanisole (696-62-8) → 5-(4-Methoxy-phenyl)-2,2-dimethyl-4,5-dihydro-[1,3]dioxepine (153867-11-9)

Guidance literature:

With palladium diacetate; triphenylphosphine; silver carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 24h;

DOI:10.3987/COM-93-6499

Reference yield:

5-(4-Methoxy-phenyl)-2,2-dimethyl-4,5-dihydro-[1,3]dioxepine (153867-11-9) → 4-(4-Methoxy-phenyl)-tetrahydro-furan-2-ol (128372-49-6)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.3987/COM-93-6499

Reference yield:

5-(4-Methoxy-phenyl)-2,2-dimethyl-4,5-dihydro-[1,3]dioxepine (153867-11-9) → β-(4-methoxyphenyl)-γ-butyrolactone (479582-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1N HCl / tetrahydrofuran / 24 h / Ambient temperature

2: 61 percent / Ag₂CO₃ / toluene / 8 h / 90 °C

With hydrogenchloride; silver carbonate; In tetrahydrofuran; toluene;

DOI:10.3987/COM-93-6499

upstream raw materials:

2,2-dimethyl-4,7-dihydro-1,3-dioxepin

para-iodoanisole

Downstream raw materials:

4-(4-Methoxy-phenyl)-tetrahydro-furan-2-ol

β-(4-methoxyphenyl)-γ-butyrolactone