1-(1-ethyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid [(S)-3-methyl-1-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-butyl]-amide

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Chemical Name:1-(1-ethyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid [(S)-3-methyl-1-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-butyl]-amide
CAS No.:1586791-00-5
Molecular Formula:C₃₂H₃₇N₅O₂S
Molecular Weight:555.744
Hs Code.:

Synonyms:1-(1-ethyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid [(S)-3-methyl-1-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-butyl]-amide

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Chemical Property of 1-(1-ethyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid [(S)-3-methyl-1-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-butyl]-amide

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Technology Process of 1-(1-ethyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid [(S)-3-methyl-1-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-butyl]-amide

There total 12 articles about 1-(1-ethyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid [(S)-3-methyl-1-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-butyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 1586790-99-9
1-(1-ethyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid [(S)-1-(N-hydroxycarbamimidoylmethyl)-3-methyl-butyl]-amide

: 98-88-4
benzoyl chloride

: 1586791-00-5
1-(1-ethyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid [(S)-3-methyl-1-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-butyl]-amide

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 120 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 1586791-15-2
1-(pentan-3-yl)-2-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxylic acid

: 1586791-00-5
1-(1-ethyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid [(S)-3-methyl-1-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-butyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

2: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran; methanol / Reflux

3: potassium carbonate / tetrahydrofuran / 0.25 h / 120 °C / Microwave irradiation

With 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1586791-00-5
1-(1-ethyl-propyl)-2-thiophen-2-ylmethyl-1H-benzoimidazole-5-carboxylic acid [(S)-3-methyl-1-(5-phenyl-[1,2,4]oxadiazol-3-ylmethyl)-butyl]-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 4 h / 3750.38 Torr

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

4.1: hydrogenchloride / 0.17 h / 120 °C / Microwave irradiation

5.1: sodium hydroxide; water / methanol / 0.08 h / 110 °C / Microwave irradiation

5.2: pH 5

6.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

7.1: hydroxylamine hydrochloride; triethylamine / tetrahydrofuran; methanol / Reflux

8.1: potassium carbonate / tetrahydrofuran / 0.25 h / 120 °C / Microwave irradiation

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; palladium 10% on activated carbon; hydroxylamine hydrochloride; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;