3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester

Base Information

Chemical Name:3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester
CAS No.:1137671-59-0
Molecular Formula:C₂₈H₂₆N₄O₄
Molecular Weight:482.539
Hs Code.:

Synonyms:3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester

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Chemical Property of 3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester

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Technology Process of 3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester

There total 8 articles about 3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1137671-58-9
(E)-3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-acrylic acid methyl ester

: 1137671-59-0
3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester

Guidance literature:: With hydrogen; 5%-palladium/activated carbon; In tetrahydrofuran; ethanol; for 3h; under 760.051 Torr;

Reference yield:

: C₂₈H₂₄N₄O₄

: 1137671-59-0
3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; ethanol; at 20 ℃; for 3h; under 760.051 Torr;
DOI:10.1021/acs.jmedchem.7b00173

Reference yield:

: 1137671-55-6
4-amino-N′-(4-methoxybenzoyl)-3-nitrobenzohydrazide

: 1137671-59-0
3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Burgess Reagent / tetrahydrofuran / 0.33 h / 150 °C / Microwave irradiation

2: hydrogen; platinum(IV) oxide / ethanol; ethyl acetate / 72 h / 20 °C / 760.05 Torr

3: oxone / N,N-dimethyl-formamide; water / 0.33 h / 20 °C

4: 5%-palladium/activated carbon; hydrogen / ethanol; tetrahydrofuran / 3 h / 20 °C / 760.05 Torr

With platinum(IV) oxide; Burgess Reagent; 5%-palladium/activated carbon; oxone; hydrogen; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00173