4-amino-N′-(4-methoxybenzoyl)-3-nitrobenzohydrazide

Base Information

• Chemical Name: 4-amino-N′-(4-methoxybenzoyl)-3-nitrobenzohydrazide
• CAS No.: 1137671-55-6
• Molecular Formula: C₁₅H₁₄N₄O₅
• Molecular Weight: 330.3
• Mol file: 1137671-55-6.mol

Synonyms:4-amino-N′-(4-methoxybenzoyl)-3-nitrobenzohydrazide

Chemical Property of 4-amino-N′-(4-methoxybenzoyl)-3-nitrobenzohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-amino-N′-(4-methoxybenzoyl)-3-nitrobenzohydrazide

There total 1 articles about 4-amino-N′-(4-methoxybenzoyl)-3-nitrobenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-methoxybenzoic acid hydrazide (3290-99-1) + 4-amino-3-nitrobenzoic acid (1588-83-6) → 4-amino-N′-(4-methoxybenzoyl)-3-nitrobenzohydrazide (1137671-55-6)

Guidance literature:

4-methoxybenzoic acid hydrazide; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

4-amino-3-nitrobenzoic acid; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.7b00173

Reference yield: 70.0%

4-amino-N′-(4-methoxybenzoyl)-3-nitrobenzohydrazide (1137671-55-6) → 4-(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-2-nitroaniline (1137671-56-7)

Guidance literature:

With Burgess Reagent; In tetrahydrofuran; at 150 ℃; for 0.333333h; Microwave irradiation;

DOI:10.1021/acs.jmedchem.7b00173

Reference yield:

4-amino-N′-(4-methoxybenzoyl)-3-nitrobenzohydrazide (1137671-55-6) → 3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester (1137671-59-0)

Guidance literature:

Multi-step reaction with 4 steps

1: Burgess Reagent / tetrahydrofuran / 0.33 h / 150 °C / Microwave irradiation

2: hydrogen; platinum(IV) oxide / ethanol; ethyl acetate / 72 h / 20 °C / 760.05 Torr

3: oxone / N,N-dimethyl-formamide; water / 0.33 h / 20 °C

4: 5%-palladium/activated carbon; hydrogen / ethanol; tetrahydrofuran / 3 h / 20 °C / 760.05 Torr

With platinum(IV) oxide; Burgess Reagent; 5%-palladium/activated carbon; oxone; hydrogen; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b00173

upstream raw materials:

4-methoxybenzoic acid hydrazide

4-amino-3-nitrobenzoic acid

Downstream raw materials:

4-(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)-2-nitroaniline

3-(4-{6-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]-1H-benzoimidazol-2-yl}-3,5-dimethylphenyl)-propionic acid methyl ester

4-(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)benzene-1,2-diamine