N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)methyl)-2-(4-trifluoromethylphenyl)acetamide

Base Information

Chemical Name:N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)methyl)-2-(4-trifluoromethylphenyl)acetamide
CAS No.:1259536-66-7
Molecular Formula:C₂₃H₁₆F₆N₄O₂
Molecular Weight:494.396
Hs Code.:

Synonyms:N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)methyl)-2-(4-trifluoromethylphenyl)acetamide

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Chemical Property of N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)methyl)-2-(4-trifluoromethylphenyl)acetamide

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Technology Process of N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)methyl)-2-(4-trifluoromethylphenyl)acetamide

There total 5 articles about N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)methyl)-2-(4-trifluoromethylphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259537-05-7
5-aminomethyl-3-phenyl-2-trifluoromethyl-pyrazole[1,5-a]pyrimidin-7(4H)-one

: 32857-62-8
4-Trifluoromethylphenylacetic acid

: 1259536-66-7
N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)methyl)-2-(4-trifluoromethylphenyl)acetamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

: 1259536-96-3
C₁₀H₅F₃NO^(1-)*Na⁽¹⁺⁾

: 1259536-66-7
N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)methyl)-2-(4-trifluoromethylphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazinium sulfate; carbonic acid dimethyl ester / 12 h / 80 °C

2: acetic acid / 4 h / Reflux

3: N,N-dimethyl-formamide / 8 h / 100 °C

4: hydrazine hydrate / ethanol / 0.5 h / Reflux

5: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; hydrazine hydrate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; carbonic acid dimethyl ester; hydrazinium sulfate; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 140-29-4
phenylacetonitrile

: 1259536-66-7
N-((2-trifluoromethyl-3-phenyl-7-oxy-4,7-dihydro-pyrazolo[1,5-a]pyrimidin-5-yl)methyl)-2-(4-trifluoromethylphenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: sodium ethanolate / ethanol / 2 h / Reflux

2: hydrazinium sulfate; carbonic acid dimethyl ester / 12 h / 80 °C

3: acetic acid / 4 h / Reflux

4: N,N-dimethyl-formamide / 8 h / 100 °C

5: hydrazine hydrate / ethanol / 0.5 h / Reflux

6: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; hydrazine hydrate; sodium ethanolate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; carbonic acid dimethyl ester; hydrazinium sulfate; In ethanol; dichloromethane; N,N-dimethyl-formamide;