11β-(3,4-difluorophenyl)-17α-ethynyl-17β-[(1-oxopropyl)amino]estra-4,9-dien-3-one

Base Information

Chemical Name:11β-(3,4-difluorophenyl)-17α-ethynyl-17β-[(1-oxopropyl)amino]estra-4,9-dien-3-one
CAS No.:940932-51-4
Molecular Formula:C₂₉H₃₁F₂NO₂
Molecular Weight:463.567
Hs Code.:

Synonyms:11β-(3,4-difluorophenyl)-17α-ethynyl-17β-[(1-oxopropyl)amino]estra-4,9-dien-3-one

Suppliers and Price of 11β-(3,4-difluorophenyl)-17α-ethynyl-17β-[(1-oxopropyl)amino]estra-4,9-dien-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 11β-(3,4-difluorophenyl)-17α-ethynyl-17β-[(1-oxopropyl)amino]estra-4,9-dien-3-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 11β-(3,4-difluorophenyl)-17α-ethynyl-17β-[(1-oxopropyl)amino]estra-4,9-dien-3-one

There total 10 articles about 11β-(3,4-difluorophenyl)-17α-ethynyl-17β-[(1-oxopropyl)amino]estra-4,9-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 940932-58-1
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-[(1-oxopropyl)amino]estr-9-ene

: 940932-51-4
11β-(3,4-difluorophenyl)-17α-ethynyl-17β-[(1-oxopropyl)amino]estra-4,9-dien-3-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 5h;
DOI:10.1021/ol070447d

Reference yield:

: 940932-56-9
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-(N-hydroxylamino)estr-9-ene

: 940932-51-4
11β-(3,4-difluorophenyl)-17α-ethynyl-17β-[(1-oxopropyl)amino]estra-4,9-dien-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / Na₂B₄O₇; aq. HCl; 2-mercaptoethyl ether / FeSO₄(NH₄)2SO₄ / tetrahydrofuran; ethanol / 5 h / Heating

2: 90 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: 97 percent / aq. TFA / CH₂Cl₂ / 5 h / 0 °C

With hydrogenchloride; borax; triethylamine; trifluoroacetic acid; FeSO₄(NH₄)2SO₄; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol070447d

Reference yield:

: 940932-55-8
11β-(3,4-difluorophenyl)-3,3-[1,2-ethanediylbis(oxy)]-17α-ethynyl-5α-hydroxy-17β-nitroestr-9-ene

: 940932-51-4
11β-(3,4-difluorophenyl)-17α-ethynyl-17β-[(1-oxopropyl)amino]estra-4,9-dien-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: Zn; aq. NH₄Cl / tetrahydrofuran; ethanol / 0.5 h

2: 82 percent / Na₂B₄O₇; aq. HCl; 2-mercaptoethyl ether / FeSO₄(NH₄)2SO₄ / tetrahydrofuran; ethanol / 5 h / Heating

3: 90 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: 97 percent / aq. TFA / CH₂Cl₂ / 5 h / 0 °C

With hydrogenchloride; borax; ammonium chloride; triethylamine; trifluoroacetic acid; zinc; FeSO₄(NH₄)2SO₄; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol070447d