Technology Process of (S)-3-[(S)-1-(3,3-diphenylpropyl)-3-methylpyrrolidin-3-yl] 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
There total 18 articles about (S)-3-[(S)-1-(3,3-diphenylpropyl)-3-methylpyrrolidin-3-yl] 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(R)-5-(methoxycarbonyl)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid;
With
oxalyl dichloride;
In
dichloromethane; N,N-dimethyl-formamide;
at 25 ℃;
Cooling with ice;
(S)-1-(3,3-diphenylpropyl)-3-methylpyrrolidin-3-ol;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 25 ℃;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: hydrogenchloride / 1,4-dioxane
2.1: potassium carbonate / acetonitrile / 12 h / 85 °C
3.1: (2S,3S)-di-4-toluoyltartaric acid / isopropyl alcohol / 90 °C
4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 25 °C / Cooling with ice
4.2: 25 °C / Cooling with ice
With
hydrogenchloride; oxalyl dichloride; (2S,3S)-di-4-toluoyltartaric acid; potassium carbonate;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: diisobutylaluminium hydride / dichloromethane; toluene / 12 h / -20 - 25 °C
2.1: triethylamine / dichloromethane / 0.5 h / 0 °C
2.2: 25 °C
3.1: potassium carbonate / acetonitrile / 12 h / 85 °C
4.1: (2S,3S)-di-4-toluoyltartaric acid / isopropyl alcohol / 90 °C
5.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 25 °C / Cooling with ice
5.2: 25 °C / Cooling with ice
With
oxalyl dichloride; (2S,3S)-di-4-toluoyltartaric acid; diisobutylaluminium hydride; potassium carbonate; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile;
