tert-Butyl 3-hydroxy-3-Methylpyrrolidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 3-hydroxy-3-Methylpyrrolidine-1-carboxylate
• CAS No.: 412278-02-5
• Molecular Formula: C10H19NO3
• Molecular Weight: 201.266
• Hs Code.: 2933990090
• Mol file: 412278-02-5.mol

Synonyms:tert-butyl 3-hydroxy-3-methyl-pyrrolidine-1-carboxylate;3-hydroxy-3-methylpyrrolidine-carboxylic acid tert-butyl ester;

Chemical Property of tert-Butyl 3-hydroxy-3-Methylpyrrolidine-1-carboxylate

Chemical Property:

• Boiling Point: 277.2±33.0 °C(Predicted)
• PKA: 14.80±0.20(Predicted)
• PSA: 49.77000
• Density: 1.103±0.06 g/cm3(Predicted)
• LogP: 1.31610
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl3-Hydroxy-3-methylpyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-Butyl 3-hydroxy-3-Methylpyrrolidine-1-carboxylate

There total 3 articles about tert-Butyl 3-hydroxy-3-Methylpyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methylmagnesium bromide (75-16-1) + 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (101385-93-7) → rac-tert-butyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate (412278-02-5)

Guidance literature:

In diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 64.0%

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (101385-93-7) + methyl iodide (74-88-4) → rac-tert-butyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate (412278-02-5)

Guidance literature:

With iodine; magnesium; In diethyl ether; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

methyl magnesium iodide (917-64-6) + 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester (101385-93-7) → rac-tert-butyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate (412278-02-5)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -20 ℃; for 3h;

upstream raw materials:

methylmagnesium bromide

3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester

methyl iodide

methyl magnesium iodide

Downstream raw materials:

(4S)-3-[1-(3,3-diphenylpropyl)-3-methylpyrrolidin-3-yl]5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

(R)-1-(3,3-diphenylpropyl)-3-methylpyrrolidin-3-ol

(4S)-3-[3-methyl-1-(3-phenylpropyl)pyrrolidinyl-3-yl]-5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

3-methyl-1-phenylethylpyrrolidin-3-ol