N⁶0-(4,4'-dimethoxytrityl)-2'-O-tosyladenosine

Base Information

• Chemical Name: N⁶0-(4,4'-dimethoxytrityl)-2'-O-tosyladenosine
• CAS No.: 109923-56-0
• Molecular Formula: C₃₈H₃₇N₅O₈S
• Molecular Weight: 723.806
• Mol file: 109923-56-0.mol

Synonyms:N⁶0-(4,4'-dimethoxytrityl)-2'-O-tosyladenosine

Chemical Property of N⁶0-(4,4'-dimethoxytrityl)-2'-O-tosyladenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶0-(4,4'-dimethoxytrityl)-2'-O-tosyladenosine

There total 7 articles about N⁶0-(4,4'-dimethoxytrityl)-2'-O-tosyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N6,O5'-bis(4,4'-dimethoxytrityl)-2'-O-tosyladenosine (109923-55-9) → N60-(4,4'-dimethoxytrityl)-2'-O-tosyladenosine (109923-56-0)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; for 3h; Ambient temperature;

DOI:10.1246/bcsj.61.2437

Reference yield:

Toluene-4-sulfonic acid (2R,3R,4R,5R)-2-(6-{[bis-(4-methoxy-phenyl)-phenyl-methyl]-amino}-purin-9-yl)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester → N60-(4,4'-dimethoxytrityl)-2'-O-tosyladenosine (109923-56-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h; Yield given; Ambient temperature;

DOI:10.1246/bcsj.61.2437

Reference yield:

3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-adenosine (69504-03-6) → N60-(4,4'-dimethoxytrityl)-2'-O-tosyladenosine (109923-56-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / pyridine / 17 h / Ambient temperature

2: pyridine / 120 h / Ambient temperature

3: tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;

DOI:10.1246/bcsj.61.2437

upstream raw materials:

N⁶,O⁵'-bis(4,4'-dimethoxytrityl)-2'-O-tosyladenosine

3',5'-bis-O-(tert-butyldimethylsilyl)-β-D-adenosine

4,4'-dimethoxytrityl chloride

p-toluenesulfonyl chloride