(4R,5S)-4-(2,4-difluorophenyl)-5-methyl-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3,2-dioxathiolane 2,2-dioxide

Base Information

Chemical Name:(4R,5S)-4-(2,4-difluorophenyl)-5-methyl-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3,2-dioxathiolane 2,2-dioxide
CAS No.:138373-72-5
Molecular Formula:C₁₂H₁₁F₂N₃O₄S
Molecular Weight:331.3
Hs Code.:

Synonyms:(4R,5S)-4-(2,4-difluorophenyl)-5-methyl-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3,2-dioxathiolane 2,2-dioxide

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Chemical Property of (4R,5S)-4-(2,4-difluorophenyl)-5-methyl-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3,2-dioxathiolane 2,2-dioxide

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Technology Process of (4R,5S)-4-(2,4-difluorophenyl)-5-methyl-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3,2-dioxathiolane 2,2-dioxide

There total 8 articles about (4R,5S)-4-(2,4-difluorophenyl)-5-methyl-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3,2-dioxathiolane 2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 138373-71-4
(4R,5S)-4-(2,4-difluorophenyl)-5-methyl-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3,2-dioxathiolane 2-oxide

: 138373-72-5
(4R,5S)-4-(2,4-difluorophenyl)-5-methyl-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3,2-dioxathiolane 2,2-dioxide

Guidance literature:: With sodium periodate; ruthenium trichloride; In water; acetonitrile; for 0.666667h; Ambient temperature;
DOI:10.1248/cpb.39.2241

Reference yield:

: 126918-32-9
(2S)-3-(2,4-Difluorophenyl)-3-buten-2-ol

: 138373-72-5
(4R,5S)-4-(2,4-difluorophenyl)-5-methyl-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3,2-dioxathiolane 2,2-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: t-BuOOH / VO(acac)2 / benzene / Ambient temperature

2: 1) NaH / 1) DMF, 65 deg C, 2h

3: 100 percent / SOCl₂, NEt₃ / CH₂Cl₂ / 0.25 h / 0 °C

4: 83 percent / NaIO₄ / RuCl₃*3H₂O / acetonitrile; H₂O / 0.67 h / Ambient temperature

With tert.-butylhydroperoxide; sodium periodate; thionyl chloride; sodium hydride; triethylamine; ruthenium trichloride; bis(acetylacetonate)oxovanadium; In dichloromethane; water; acetonitrile; benzene;
DOI:10.1248/cpb.39.2241

Reference yield:

: 135270-11-0
(2R,3S)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-butane-2,3-diol

: 138373-72-5
(4R,5S)-4-(2,4-difluorophenyl)-5-methyl-4-<(1H-1,2,4-triazol-1-yl)methyl>-1,3,2-dioxathiolane 2,2-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / SOCl₂, NEt₃ / CH₂Cl₂ / 0.25 h / 0 °C

2: 83 percent / NaIO₄ / RuCl₃*3H₂O / acetonitrile; H₂O / 0.67 h / Ambient temperature

With sodium periodate; thionyl chloride; triethylamine; ruthenium trichloride; In dichloromethane; water; acetonitrile;
DOI:10.1248/cpb.39.2241