(2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Base Information

Chemical Name:(2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol
CAS No.:126917-48-4
Molecular Formula:C₁₂H₁₂F₂N₆O
Molecular Weight:294.264
Hs Code.:

Synonyms:(2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Suppliers and Price of (2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of (2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

There total 21 articles about (2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.8%

: 124627-86-7,132563-70-3,132563-77-0,135270-07-4,135270-10-9,135270-13-2,141611-70-3,127000-90-2
1-(((2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiran-2-yl)-methyl)-1H-1,2,4-triazole

: 126917-48-4
(2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 8h;
DOI:10.1016/j.ejmech.2017.10.081

Reference yield:

: 126918-14-7
(2S)-2',4'-Difluoro-2-hydroxypropiophenone

: 126917-48-4
(2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / Ambient temperature

2: diethyl ether / 1 h / 0 °C

3: 92 percent / p-TsOH / methanol / 12 h / Ambient temperature

4: t-BuOOH / VO(acac)2 / benzene / Ambient temperature

5: 1) NaH / 1) DMF, 65 deg C, 2h

6: 100 percent / SOCl₂, NEt₃ / CH₂Cl₂ / 0.25 h / 0 °C

7: 83 percent / NaIO₄ / RuCl₃*3H₂O / acetonitrile; H₂O / 0.67 h / Ambient temperature

8: 1) NaN₃, 2) H₂SO₄ / 1) DMF, 50 deg C, 2h, 2) 50 deg C, 4h

With tert.-butylhydroperoxide; sodium periodate; thionyl chloride; sodium azide; sulfuric acid; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; triethylamine; ruthenium trichloride; bis(acetylacetonate)oxovanadium; In methanol; diethyl ether; dichloromethane; water; acetonitrile; benzene;
DOI:10.1248/cpb.39.2241

Reference yield:

: 126918-15-8
(S)-2-(p-toluenesulfonyloxy)-2',4'-difluoropropiophenone

: 126917-48-4
(2R,3R)-3-Azido-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:: Multi-step reaction with 9 steps

1: aq. LiOH / dimethylformamide / 1 h / -15 °C

2: 90 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / Ambient temperature

3: diethyl ether / 1 h / 0 °C

4: 92 percent / p-TsOH / methanol / 12 h / Ambient temperature

5: t-BuOOH / VO(acac)2 / benzene / Ambient temperature

6: 1) NaH / 1) DMF, 65 deg C, 2h

7: 100 percent / SOCl₂, NEt₃ / CH₂Cl₂ / 0.25 h / 0 °C

8: 83 percent / NaIO₄ / RuCl₃*3H₂O / acetonitrile; H₂O / 0.67 h / Ambient temperature

9: 1) NaN₃, 2) H₂SO₄ / 1) DMF, 50 deg C, 2h, 2) 50 deg C, 4h

With tert.-butylhydroperoxide; lithium hydroxide; sodium periodate; thionyl chloride; sodium azide; sulfuric acid; pyridinium p-toluenesulfonate; sodium hydride; toluene-4-sulfonic acid; triethylamine; ruthenium trichloride; bis(acetylacetonate)oxovanadium; In methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1248/cpb.39.2241