{5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenyl}-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl]-amine

Base Information

Chemical Name:{5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenyl}-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl]-amine
CAS No.:1273550-53-0
Molecular Formula:C₂₆H₃₄ClFN₄O₃Si
Molecular Weight:533.118
Hs Code.:

Synonyms:{5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenyl}-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl]-amine

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Chemical Property of {5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenyl}-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl]-amine

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Technology Process of {5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenyl}-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl]-amine

There total 10 articles about {5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenyl}-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: (R)-5-(4-fluoro-phenyl)-morpholin-3-yl-{5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenylamine} semicarbazone

: 1273550-53-0
{5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenyl}-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl]-amine

Guidance literature:: With triethylamine; dichlorotriphenylphosphorane; In acetonitrile; for 0.5h; Reflux;

Reference yield:

: 619-10-3
5-nitro-2-chlorophenol

: 1273550-53-0
{5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenyl}-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl]-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium chloride; iron / ethanol; water / 2 h / Reflux

2.1: tetra-N-butylammonium tribromide / dichloromethane; methanol / 0.33 h / 20 °C

3.1: sodium iodide; caesium carbonate / 1-methyl-pyrrolidin-2-one / 2 h / 100 °C

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 20 h / 110 °C / Inert atmosphere

5.1: triethylamine / toluene; diethyl ether / 0.25 h / 0 °C

5.2: 0.33 h / 20 °C

6.1: tetrahydrofuran / 1 h / 20 °C

7.1: triethylamine; dichlorotriphenylphosphorane / acetonitrile / 0.5 h / Reflux

With tetra-N-butylammonium tribromide; iron; potassium carbonate; ammonium chloride; caesium carbonate; triethylamine; sodium iodide; dichlorotriphenylphosphorane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 1232505-79-1
2-bromo-5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-phenylamine

: 1273550-53-0
{5-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxy]-4-chloro-2-methyl-phenyl}-[(R)-5-(4-fluoro-phenyl)-5,6-dihydro-8H-[1,2,4]triazolo[3,4-c][1,4]oxazin-3-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 20 h / 110 °C / Inert atmosphere

2.1: triethylamine / toluene; diethyl ether / 0.25 h / 0 °C

2.2: 0.33 h / 20 °C

3.1: tetrahydrofuran / 1 h / 20 °C

4.1: triethylamine; dichlorotriphenylphosphorane / acetonitrile / 0.5 h / Reflux

With potassium carbonate; triethylamine; dichlorotriphenylphosphorane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; toluene; acetonitrile;