(R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one

Base Information

Chemical Name:(R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one
CAS No.:1410805-29-6
Molecular Formula:C₅₂H₇₅BrN₂O₁₀Si₃
Molecular Weight:1052.34
Hs Code.:

(R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one

Synonyms:(R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one

Suppliers and Price of (R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one

There total 20 articles about (R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: (R)-3-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)isoxazol-4-yl)-3-(triethylsilyloxy)propanal oxime

: 1410804-98-6
(R)-3-(3-(benzyloxy)-2-ethynylphenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)methoxy)-butan-2-one

: 1410805-29-6
(R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one

Guidance literature:: With pyridine; N-chloro-succinimide; N-ethyl-N,N-diisopropylamine; In chloroform; at 20 - 60 ℃; for 44.75h; Inert atmosphere;
DOI:10.1021/ol302691j

Reference yield:

: 1410805-21-8
C₂₆H₄₃NO₆Si₂

: 1410805-29-6
(R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: diisobutylaluminium hydride / hexane; toluene / 2 h / -78 °C / Inert atmosphere

2.1: sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 1 h / 0 °C / Inert atmosphere

3.1: pentane; diethyl ether / 0.75 h / -78 - 0 °C / Inert atmosphere

4.1: pyridine hydrogenfluoride; THF-pyridine / tetrahydrofuran / 0.75 h / 20 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

5.1: acetic acid / methanol / 26 h / 0 °C / Inert atmosphere

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / tetrahydrofuran; aq. phosphate buffer; acetone / 2 h / 20 °C / pH 7 / Inert atmosphere

7.1: sodium periodate / tetrahydrofuran; aq. phosphate buffer / 0.5 h / 20 °C / pH 7 / Inert atmosphere

8.1: hydroxylamine hydrochloride; pyridine / ethanol / 1 h / 0 °C / Inert atmosphere

9.1: pyridine; N-ethyl-N,N-diisopropylamine; N-chloro-succinimide / chloroform / 44.75 h / 20 - 60 °C / Inert atmosphere

With pyridine; sodium periodate; N-chloro-succinimide; osmium(VIII) oxide; THF-pyridine; hydroxylamine hydrochloride; sulfur trioxide pyridine complex; diisobutylaluminium hydride; pyridine hydrogenfluoride; acetic acid; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; aq. phosphate buffer; diethyl ether; ethanol; hexane; dichloromethane; chloroform; dimethyl sulfoxide; acetone; toluene; pentane;
DOI:10.1021/ol302691j

Reference yield:

: C₂₈H₄₉NO₇Si₂

: 1410805-29-6
(R)-3-(3-(benzyloxy)-2-(3-((R)-2-(3-(benzyloxy)-5-((S)-1-(tert-butyldimethylsilyloxy)-2-hydroxyethyl)-isoxazol-4-yl)-2-(triethylsilyloxy)ethyl)isoxazol-5-yl)phenyl)-1-bromo-3-((2-(trimethylsilyl)ethoxy)me-thoxy)butan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium periodate / tetrahydrofuran; aq. phosphate buffer / 0.5 h / 20 °C / pH 7 / Inert atmosphere

2: hydroxylamine hydrochloride; pyridine / ethanol / 1 h / 0 °C / Inert atmosphere

3: pyridine; N-ethyl-N,N-diisopropylamine; N-chloro-succinimide / chloroform / 44.75 h / 20 - 60 °C / Inert atmosphere

With pyridine; sodium periodate; N-chloro-succinimide; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; aq. phosphate buffer; ethanol; chloroform;
DOI:10.1021/ol302691j