2-(2-cyanoethyl)-4-phenyl-5,6,7,8-tetrahydro-1(2H)phthalazinone

Base Information

• Chemical Name: 2-(2-cyanoethyl)-4-phenyl-5,6,7,8-tetrahydro-1(2H)phthalazinone
• CAS No.: 561006-91-5
• Molecular Formula: C₁₇H₁₇N₃O
• Molecular Weight: 279.341
• Mol file: 561006-91-5.mol

Synonyms:2-(2-cyanoethyl)-4-phenyl-5,6,7,8-tetrahydro-1(2H)phthalazinone

Chemical Property of 2-(2-cyanoethyl)-4-phenyl-5,6,7,8-tetrahydro-1(2H)phthalazinone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-cyanoethyl)-4-phenyl-5,6,7,8-tetrahydro-1(2H)phthalazinone

There total 2 articles about 2-(2-cyanoethyl)-4-phenyl-5,6,7,8-tetrahydro-1(2H)phthalazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acrylonitrile (107-13-1,25014-41-9) + 4-phenyl-5,6,7,8-tetrahydrophthalazin-1(2H)-one (154810-22-7) → 2-(2-cyanoethyl)-4-phenyl-5,6,7,8-tetrahydro-1(2H)phthalazinone (561006-91-5)

Guidance literature:

With potassium carbonate; In ethanol; for 5h;

Reference yield:

cis-4-phenyl-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-one → 2-(2-cyanoethyl)-4-phenyl-5,6,7,8-tetrahydro-1(2H)phthalazinone (561006-91-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / Br₂; glacial acetic acid / 2 h / Heating

2: 96 percent / aq. K₂CO₃ / ethanol / 5 h

With bromine; potassium carbonate; acetic acid; In ethanol;

Reference yield: 93.0%

2-(2-cyanoethyl)-4-phenyl-5,6,7,8-tetrahydro-1(2H)phthalazinone (561006-91-5) → 3-(4-phenyl-5,6,7,8-tetrahydro-1(2H)phthalazinon-2-yl)propanoic acid

Guidance literature:

With hydrogenchloride; In dimethyl sulfoxide; for 10h; Heating;

upstream raw materials:

acrylonitrile

4-phenyl-5,6,7,8-tetrahydrophthalazin-1(2H)-one