(S)-2-(4-{[2-(2-Dimethylamino-ethylamino)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-(4-{[2-(2-Dimethylamino-ethylamino)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester
CAS No.:118111-72-1
Molecular Formula:C₃₂H₄₀N₆O₆
Molecular Weight:604.706
Hs Code.:

(S)-2-(4-{[2-(2-Dimethylamino-ethylamino)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Synonyms:(S)-2-(4-{[2-(2-Dimethylamino-ethylamino)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

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Chemical Property of (S)-2-(4-{[2-(2-Dimethylamino-ethylamino)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

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Technology Process of (S)-2-(4-{[2-(2-Dimethylamino-ethylamino)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

There total 4 articles about (S)-2-(4-{[2-(2-Dimethylamino-ethylamino)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 108-00-9
N,N-dimethylethylenediamine

: 112888-80-9
Diethyl N-<4--N-prop-2-ynylamino>benzoyl>-L-glutamate

: 118111-72-1
(S)-2-(4-{[2-(2-Dimethylamino-ethylamino)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Guidance literature:: In various solvent(s); at 100 ℃; for 6h;
DOI:10.1021/jm00123a010

Reference yield:

: 76858-72-5
diethyl N-(4-(prop-2-ynylamino)benzoyl)-L-glutamate

: 118111-72-1
(S)-2-(4-{[2-(2-Dimethylamino-ethylamino)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / CaCO₃ / dimethylformamide / 16 h / 60 °C

2: 56 percent / various solvent(s) / 6 h / 100 °C

With calcium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00123a010

Reference yield:

: 118111-59-4
6-Bromomethyl-2-chloro-3H-quinazolin-4-one

: 118111-72-1
(S)-2-(4-{[2-(2-Dimethylamino-ethylamino)-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl]-prop-2-ynyl-amino}-benzoylamino)-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / CaCO₃ / dimethylformamide / 16 h / 60 °C

2: 56 percent / various solvent(s) / 6 h / 100 °C

With calcium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm00123a010