Technology Process of (2R,6R)-2,6,10-trimethyl-1-(phenylthio)undecane
There total 7 articles about (2R,6R)-2,6,10-trimethyl-1-(phenylthio)undecane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) n-BuLi, HMPA / 1) THF, hexane, -40 deg C, 1 h, 2) -70 deg C, 3 h
2: 99 percent / Na-Hg / ethanol / 48 h / Ambient temperature
3: 90 percent / p-toluenesulfonic acid monohydrate / methanol / 1 h / Ambient temperature
4: pyridine / 12 h
5: 1) NaOH / 1) MeOH, 1 h, room temperature, 2) 12 h, reflux
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; sodium amalgam; toluene-4-sulfonic acid;
In
methanol; ethanol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 83 percent / LiBr / dimethylformamide / 20 h / Ambient temperature
2: 1) n-BuLi, HMPA / 1) THF, hexane, -40 deg C, 1 h, 2) -70 deg C, 3 h
3: 99 percent / Na-Hg / ethanol / 48 h / Ambient temperature
4: 90 percent / p-toluenesulfonic acid monohydrate / methanol / 1 h / Ambient temperature
5: pyridine / 12 h
6: 1) NaOH / 1) MeOH, 1 h, room temperature, 2) 12 h, reflux
With
pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; sodium amalgam; toluene-4-sulfonic acid; lithium bromide;
In
methanol; ethanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 90 percent / p-toluenesulfonic acid monohydrate / methanol / 1 h / Ambient temperature
2: pyridine / 12 h
3: 1) NaOH / 1) MeOH, 1 h, room temperature, 2) 12 h, reflux
With
pyridine; sodium hydroxide; toluene-4-sulfonic acid;
In
methanol;
