2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid

Base Information

• Chemical Name: 2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid
• CAS No.: 879609-79-7
• Molecular Formula: C₁₂H₁₅BF₃NO₄
• Molecular Weight: 305.062
• Mol file: 879609-79-7.mol

Synonyms:2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid

Chemical Property of 2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid

Chemical Property:

Purity/Quality:

2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronicacid 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid

There total 2 articles about 2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyl<3-(trifluoromethyl)phenyl>-carbamate (109134-07-8) → 2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid (879609-79-7)

Guidance literature:

t-butyl<3-(trifluoromethyl)phenyl>-carbamate; With sec.-butyllithium; In tetrahydrofuran; cyclohexane; at -40 ℃; for 1.16667h;

With Trimethyl borate; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; for 0.333333h;

With potassium dihydrogenphosphate; water; In tetrahydrofuran; cyclohexane;

Reference yield:

C14H19BF3NO4 (659731-72-3) → 2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid (879609-79-7)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2008.07.112

Reference yield: 35.0%

4,6-dichloropyrimidine (1193-21-1) + 2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid (879609-79-7) → tert-butyl 2-(6-chloropyrimidin-4-yl)-5-(trifluoromethyl)phenylcarbamate (659731-56-3)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 70 ℃; for 14h;

DOI:10.1021/jm7014638

upstream raw materials:

C₁₄H₁₉BF₃NO₄

t-butyl<3-(trifluoromethyl)phenyl>-carbamate

Downstream raw materials:

tert-Butyl 2-(6-(3-amino-2-oxo-1,2-dihydroquinoxalin-5-yloxy)-2-((S)-1-methoxypropan-2-ylamino)pyrimidin-4-yl)-5-(trifluoromethyl)phenylcarbamate

tert-butyl 2-(6-chloropyrimidin-4-yl)-5-(trifluoromethyl)phenylcarbamate

N-(2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)phenyl)acetamide

N-(2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)phenyl)diacetamide