N-(2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)phenyl)acetamide

Base Information

• Chemical Name: N-(2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)phenyl)acetamide
• CAS No.: 913296-80-7
• Molecular Formula: C₁₄H₁₀ClF₃N₂O
• Molecular Weight: 314.694
• Mol file: 913296-80-7.mol

Synonyms:N-(2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)phenyl)acetamide

Chemical Property of N-(2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N-(2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)phenyl)acetamide

There total 1 articles about N-(2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-bromopyridine (73583-37-6) + 2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid (879609-79-7) + acetic anhydride (108-24-7) → N-(2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)phenyl)acetamide (913296-80-7) + N-(2-(2-chloropyridin-4-yl)-5-(trifluoromethyl)phenyl)diacetamide (913296-79-4)

Guidance literature:

2-chloro-4-bromopyridine; 2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; toluene; at 100 ℃; for 18h;

acetic anhydride; With dmap; In dichloromethane; at 40 ℃; for 16h;

upstream raw materials:

2-chloro-4-bromopyridine

2-(tert-butoxycarbonylamino)-4-(trifluoromethyl)phenylboronic acid

acetic anhydride