(1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol

Base Information

Chemical Name:(1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol
CAS No.:1034606-41-1
Molecular Formula:C₂₆H₂₈F₂N₂O₂
Molecular Weight:438.517
Hs Code.:

Synonyms:(1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol

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Chemical Property of (1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol

Chemical Property:

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Technology Process of (1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol

There total 13 articles about (1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1034606-52-4
(4S,5S)-4-(3,5-difluorobenzyl)-5-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)oxazolidin-2-one

: 1034606-41-1
(1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol

Guidance literature:: With lithium hydroxide; water; In ethanol; at 60 ℃;

Reference yield:

: C₂₇H₂₆F₂N₂O₃

: 1034606-41-1
(1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol

: 1345968-25-3
C₂₆H₂₈F₂N₂O₂

Guidance literature:: With sodium hydroxide; In ethanol; at 60 ℃;
DOI:10.1016/j.bmcl.2011.06.116

Reference yield:

: 877078-49-4
(S)-4-benzyl-3-(3-(3,5-difluorophenyl)propanoyl)oxazolidin-2-one

: 1034606-41-1
(1S,2S)-1-((R)-2-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-2-amino-3-(3,5-difluorophenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / -78 °C

2: lithium hydroperoxide / tetrahydrofuran; water / 0 - 20 °C

3: diphenyl phosphoryl azide / toluene

4: trifluoroacetic acid / dichloromethane / 20 °C

5: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

6: sodium hydroxide / ethanol / 60 °C

With lithium hydroperoxide; di-n-butylboryl trifluoromethanesulfonate; diphenyl phosphoryl azide; sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 3: Curtius rearrangement;
DOI:10.1016/j.bmcl.2011.06.116