4-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)-1-methylpiperazine 1-oxide acetate

Base Information

Chemical Name:4-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)-1-methylpiperazine 1-oxide acetate
CAS No.:1307233-67-5
Molecular Formula:C₂H₄O₂*C₂₂H₂₁N₇O₃
Molecular Weight:491.506
Hs Code.:

Synonyms:4-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)-1-methylpiperazine 1-oxide acetate

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Chemical Property of 4-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)-1-methylpiperazine 1-oxide acetate

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Technology Process of 4-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)-1-methylpiperazine 1-oxide acetate

There total 8 articles about 4-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)-1-methylpiperazine 1-oxide acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1307233-44-8
(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone

: 631-61-8,92206-38-7
ammonium acetate

: 1307233-67-5
4-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)-1-methylpiperazine 1-oxide acetate

Guidance literature:: (4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)phenyl)(4-methylpiperazin-1-yl)methanone; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

ammonium acetate; In acetonitrile;

Reference yield:

: 6320-39-4
3-aminopyridin-4-ol

: 1307233-67-5
4-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)-1-methylpiperazine 1-oxide acetate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3: N-Bromosuccinimide / acetic acid / 20 °C

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 0.67 h / 130 °C / Inert atmosphere; Microwave irradiation

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane

With N-Bromosuccinimide; hexachloroethane; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 5424-01-1
3-aminopyrazinoic acid

: 1307233-67-5
4-(4-(5-amino-6-(oxazolo[4,5-c]pyridin-2-yl)pyrazin-2-yl)benzoyl)-1-methylpiperazine 1-oxide acetate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: triethylamine; triphenylphosphine; hexachloroethane / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice

3: N-Bromosuccinimide / acetic acid / 20 °C

4: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / tetrahydrofuran / 0.67 h / 130 °C / Inert atmosphere; Microwave irradiation

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane

With N-Bromosuccinimide; hexachloroethane; sodium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;