5-(1-(4-chlorophenyl)-1-(4-(methylsulfonamido)-1H-indazol-1-yl)propyl)-1,2,4-oxadiazole-3-carboxamide

Base Information

Chemical Name:5-(1-(4-chlorophenyl)-1-(4-(methylsulfonamido)-1H-indazol-1-yl)propyl)-1,2,4-oxadiazole-3-carboxamide
CAS No.:1389325-78-3
Molecular Formula:C₂₀H₁₉ClN₆O₄S
Molecular Weight:474.928
Hs Code.:

Synonyms:5-(1-(4-chlorophenyl)-1-(4-(methylsulfonamido)-1H-indazol-1-yl)propyl)-1,2,4-oxadiazole-3-carboxamide

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Chemical Property of 5-(1-(4-chlorophenyl)-1-(4-(methylsulfonamido)-1H-indazol-1-yl)propyl)-1,2,4-oxadiazole-3-carboxamide

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Technology Process of 5-(1-(4-chlorophenyl)-1-(4-(methylsulfonamido)-1H-indazol-1-yl)propyl)-1,2,4-oxadiazole-3-carboxamide

There total 9 articles about 5-(1-(4-chlorophenyl)-1-(4-(methylsulfonamido)-1H-indazol-1-yl)propyl)-1,2,4-oxadiazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389326-80-0
ethyl 5-(1-(4-chlorophenyl)-1-(4-(methylsulfonamido)-1H-indazol-1-yl)propyl)-1,2,4-oxadiazole-3-carboxylate

: 1389325-78-3
5-(1-(4-chlorophenyl)-1-(4-(methylsulfonamido)-1H-indazol-1-yl)propyl)-1,2,4-oxadiazole-3-carboxamide

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 0.75h;

Reference yield:

: 24091-92-7
methyl 2-bromo-2-(4-chlorophenyl)acetate

: 1389325-78-3
5-(1-(4-chlorophenyl)-1-(4-(methylsulfonamido)-1H-indazol-1-yl)propyl)-1,2,4-oxadiazole-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 20 °C

2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.1: water; lithium hydroxide / 1,4-dioxane / 5 h / 70 °C

6.1: 1,1'-carbonyldiimidazole / dichloromethane / 7.5 h / 20 °C

6.2: 20 °C

7.1: pyridine; trichlorophosphate / 7 h / 35 - 70 °C

8.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 20 °C

9.1: 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 20 °C

10.1: ammonia / methanol / 0.75 h / 20 °C

With 4-methyl-morpholine; pyridine; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; ammonia; water; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; methoxybenzene; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium hydroxide; trichlorophosphate; 10% Pt/activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 2942-40-7
nitro-4 indazole

: 1389325-78-3
5-(1-(4-chlorophenyl)-1-(4-(methylsulfonamido)-1H-indazol-1-yl)propyl)-1,2,4-oxadiazole-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / acetonitrile / 0.5 h

1.2: 20 °C

2.1: hydrogen; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate / 10% Pt/activated carbon / 48 h / 20 °C

3.1: sodium carbonate / 1,4-dioxane; water / 48 h / 0 - 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.1: water; lithium hydroxide / 1,4-dioxane / 5 h / 70 °C

6.1: 1,1'-carbonyldiimidazole / dichloromethane / 7.5 h / 20 °C

6.2: 20 °C

7.1: pyridine; trichlorophosphate / 7 h / 35 - 70 °C

8.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 20 °C

9.1: 4-methyl-morpholine / dichloromethane / 0.5 h / 0 - 20 °C

10.1: ammonia / methanol / 0.75 h / 20 °C

With 4-methyl-morpholine; pyridine; methyl 2-(4-chlorophenyl)-2-(4-nitro-2H-indazol-2-yl)acetate; ammonia; water; hydrogen; sodium hydride; sodium carbonate; potassium carbonate; methoxybenzene; 1,1'-carbonyldiimidazole; trifluoroacetic acid; lithium hydroxide; trichlorophosphate; 10% Pt/activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;